KLF5 and GTF2E2

Number of citations of the paper that reports this interaction (PubMedID 9089417)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KLF5	GTF2E2
Description		KLF transcription factor 5	general transcription factor IIE subunit 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIE Complex Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding MRF Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	TFIIH-class Transcription Factor Complex Binding DNA Binding RNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Skeletal Muscle Satellite Cell Differentiation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Microvillus Assembly Regulation Of Microvillus Assembly Skeletal Muscle Cell Differentiation Skeletal Muscle Tissue Regeneration Positive Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Cell Development Positive Regulation Of Transcription By Transcription Factor Localization Cellular Response To Leukemia Inhibitory Factor Cellular Response To Endothelin	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter
Pathways		Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29679657) Aspartate aminotransferase levels ( 33547301) Asthma ( 34103634) Blood urea nitrogen levels ( 31152163) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chronotype ( 30696823) Colorectal cancer ( 30529582) Colorectal cancer or advanced adenoma ( 30510241) Creatine kinase levels ( 29403010) Endometrial cancer ( 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29785010 31959993) Keratoconus ( 33649486) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pancreatic cancer ( 20101243 29422604 26098869 25086665) Prostate cancer ( 26443449 31562322) Systolic blood pressure ( 30224653) Type 2 diabetes ( 25760438)	Cognitive performance ( 20125193) Glaucoma (primary open-angle) ( 33627673) Mean corpuscular volume ( 32888494) Metabolite levels (X-11787) ( 23934736)
Interacting Genes		26 interacting genes: ANP32B ATXN3L CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F2 HDAC1 JUN NCOR1 NCOR2 NEDD4 NFKB1 PARP1 PPARG PRKCA PRKCD RARA RXRA SET SMURF2 TBP UBE2I	27 interacting genes: APP ATF7IP CCNH CDK7 ERCC3 ERCC6 EXOC8 FOS GRSF1 GTF2A1 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 JUN KAT5 KLF5 MCC MDM2 MNAT1 NUP62 PICK1 SND1 SUPT16H TBP XPA
Entrez ID		688	2961
HPRD ID		04212	01800
Ensembl ID		ENSG00000102554	ENSG00000197265
Uniprot IDs		Q13887 Q5T6X2	P29084
PDB IDs		2EBT	1D8J 1D8K 5GPY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 8BVW 8BYQ 8GXQ 8GXS 8S51 8S52 8S55 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Transcription By RNA Polymerase II Enzyme Binding DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Nucleobase-containing Compound Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cellular Response To UV DNA Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coregulator Binding Protein-containing Complex Response To Lipid Positive Regulation Of Protein Localization Cellular Response To Light Stimulus Transcription Coactivator Binding	Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Initiation Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIIH Core Complex Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIIH Holo Complex Transcription Factor TFIID Complex Nucleoplasm RNA Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Elongation Nucleotide-excision Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription Factor TFIIK Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Transcription Elongation By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process CAK-ERCC2 Complex Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Binding Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Repair Regulation Of Metabolic Process Transcription Preinitiation Complex Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Stress DNA Damage Response
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