TACR1 and TAC3

Number of citations of the paper that reports this interaction (PubMedID 12727971)
0

Data Source:
HPRD (in vitro)

		TACR1	TAC3
Description		tachykinin receptor 1	tachykinin precursor 3
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Dendrite Sperm Flagellum Cell Body Postsynaptic Membrane Sperm Head Cell Periphery Sperm Midpiece	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity	Signaling Receptor Binding Protein Binding Neuromedin K Receptor Binding Substance K Receptor Binding
	Biological Process	Aggressive Behavior Positive Regulation Of Leukocyte Migration Angiotensin-mediated Drinking Behavior Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Learning Or Memory Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Response To Ozone Positive Regulation Of Epithelial Cell Migration Response To Auditory Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Nicotine Operant Conditioning Sperm Ejaculation Eating Behavior Positive Regulation Of Vascular Permeability Response To Ethanol Positive Regulation Of Action Potential Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Vasoconstriction Positive Regulation Of Hormone Secretion Response To Pain Behavioral Response To Pain Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Stress Fiber Assembly Response To Electrical Stimulus Smooth Muscle Contraction Involved In Micturition Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility	Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Positive Regulation Of Blood Pressure Positive Regulation Of Flagellated Sperm Motility
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs		Tramadol Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Casopitant Netupitant Rolapitant Vestipitant Vofopitant Fosnetupitant	Copper
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Bipolar disorder x sex interaction ( 34099189) Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Gout ( 32238385) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Menopause (age at onset) ( 26414677) Red cell distribution width ( 28957414) Schizophrenia ( 25056061)
Interacting Genes		7 interacting genes: CCDC167 GPRASP1 GRK5 TAC1 TAC3 TAC4 TMEM147	12 interacting genes: CCDC90B ELP1 FEZ1 GPRASP1 PRB1 PRH1 PTN TACR1 TACR2 TACR3 UBC UBR1
Entrez ID		6869	6866
HPRD ID		01208	08877
Ensembl ID		ENSG00000115353	ENSG00000166863
Uniprot IDs		P25103	Q9UHF0
PDB IDs		2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP 7P00 7P02 7RMG 7RMH 7RMI 8U26	1P9F 8JBG
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Signaling Pathway Substance K Receptor Binding Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Positive Regulation Of Sensory Perception Of Pain Regulation Of Microtubule-based Movement Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Detection Of Temperature Stimulus Involved In Sensory Perception Regulation Of Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Reproductive Process Regulation Of Microtubule-based Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway G Protein-coupled Receptor Catabolic Process Regulation Of Nervous System Process Detection Of Abiotic Stimulus Receptor Ligand Activity Positive Regulation Of Cell Motility Positive Regulation Of Corticosterone Secretion Protein Localization To Nuclear Inner Membrane Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Locomotion Detection Of Stimulus Involved In Sensory Perception Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Insemination Response To Temperature Stimulus Regulation Of Corticosterone Secretion G Protein-coupled Receptor Kinase Activity Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Action Potential Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Detection Of Stimulus Antifungal Humoral Response Nuclear Membrane Negative Regulation Of Heart Rate Protein Localization To Nuclear Envelope Response To Yeast Regulation Of Cell Motility	Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Regulation Of Microtubule-based Movement Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Operant Conditioning Positive Regulation Of Muscle Contraction Sperm Midpiece Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Regulation Of Microtubule-based Process Sperm Head Positive Regulation Of Vascular Permeability Response To Auditory Stimulus Learning Regulation Of Muscle Contraction Positive Regulation Of Blood Pressure Regulation Of Reproductive Process Response To Electrical Stimulus Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Ossification Smooth Muscle Contraction Substance K Receptor Activity Regulation Of Muscle System Process Substance P Receptor Activity Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Learning Or Memory Cognition Dendrite Regeneration Angiotensin-mediated Drinking Behavior G Protein-coupled Receptor Catabolic Process Ossification Involved In Bone Remodeling G Protein-coupled Receptor Activity Prolactin Secretion Negative Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Smooth Muscle Contraction Involved In Micturition TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Acetylcholine Secretion, Neurotransmission Intestine Smooth Muscle Contraction Response To Ozone Response To Estradiol
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