TACR2 and TAC3

Number of citations of the paper that reports this interaction (PubMedID 10189055)
0

Data Source:
HPRD (in vivo)

		TACR2	TAC3
Description		tachykinin receptor 2	tachykinin precursor 3
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Sperm Flagellum Sperm Head Sperm Midpiece	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding Substance K Receptor Activity	Signaling Receptor Binding Protein Binding Neuromedin K Receptor Binding Substance K Receptor Binding
	Biological Process	Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Positive Regulation Of Acetylcholine Secretion, Neurotransmission Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Operant Conditioning Positive Regulation Of Vascular Permeability Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Smooth Muscle Contraction Response To Electrical Stimulus Prolactin Secretion Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility	Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Positive Regulation Of Blood Pressure Positive Regulation Of Flagellated Sperm Motility
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events	Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs		Saredutant	Copper
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Menopause (age at onset) ( 26414677) Red cell distribution width ( 28957414) Schizophrenia ( 25056061)
Interacting Genes		6 interacting genes: ANK3 GPRASP1 MTDH TAC1 TAC3 TAC4	12 interacting genes: CCDC90B ELP1 FEZ1 GPRASP1 PRB1 PRH1 PTN TACR1 TACR2 TACR3 UBC UBR1
Entrez ID		6865	6866
HPRD ID		01207	08877
Ensembl ID		ENSG00000075073	ENSG00000166863
Uniprot IDs		P21452	Q9UHF0
PDB IDs		7XWO	1P9F 8JBG
Enriched GO Terms of Interacting Partners?		Substance K Receptor Binding Tachykinin Receptor Signaling Pathway Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Regulation Of Microtubule-based Movement Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Regulation Of Blood Pressure Detection Of Temperature Stimulus Involved In Sensory Perception Regulation Of Reproductive Process Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Microtubule-based Process Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Regulation Of Nervous System Process Positive Regulation Of Cell Motility G Protein-coupled Receptor Catabolic Process Bicellular Tight Junction Positive Regulation Of Locomotion Detection Of Abiotic Stimulus Receptor Ligand Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Corticosterone Secretion Detection Of Stimulus Involved In Sensory Perception Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus Insemination Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential G Protein-coupled Receptor Signaling Pathway Cellular Response To Magnesium Ion Regulation Of Corticosterone Secretion Intercellular Canaliculus Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Synaptic Transmission, Cholinergic Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Negative Regulation Of Voltage-gated Potassium Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity	Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Regulation Of Microtubule-based Movement Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Operant Conditioning Positive Regulation Of Muscle Contraction Sperm Midpiece Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Regulation Of Microtubule-based Process Sperm Head Positive Regulation Of Vascular Permeability Response To Auditory Stimulus Learning Regulation Of Muscle Contraction Positive Regulation Of Blood Pressure Regulation Of Reproductive Process Response To Electrical Stimulus Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Ossification Smooth Muscle Contraction Substance K Receptor Activity Regulation Of Muscle System Process Substance P Receptor Activity Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Learning Or Memory Cognition Dendrite Regeneration Angiotensin-mediated Drinking Behavior G Protein-coupled Receptor Catabolic Process Ossification Involved In Bone Remodeling G Protein-coupled Receptor Activity Prolactin Secretion Negative Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Smooth Muscle Contraction Involved In Micturition TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Acetylcholine Secretion, Neurotransmission Intestine Smooth Muscle Contraction Response To Ozone Response To Estradiol
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