SUPT4H1 and PDLIM1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SUPT4H1	PDLIM1
Description		SPT4 homolog, DSIF elongation factor subunit	PDZ and LIM domain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex	Stress Fiber Transcription Regulator Complex Cytoplasm Cytoskeleton Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity	Transcription Coactivator Activity Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Heart Development Fibroblast Migration Maintenance Of Cell Polarity Actin Cytoskeleton Organization Establishment Or Maintenance Of Actin Cytoskeleton Polarity Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Muscle Structure Development Cell-cell Adhesion
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887) Refractive error ( 32231278)	Hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Suicide risk ( 21041247) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: ANXA5 APP EWSR1 HTATSF1 LRIF1 LRRK2 MFHAS1 NSG2 PDLIM1 SMARCA2 SUPT5H XRCC5	16 interacting genes: ACTN1 ACTN2 ACTN4 AGK GABARAPL2 GFAP MAP1LC3C MAPK6 PGS1 PITX2 PTGER4 RLIM RPS6KA5 STK35 SUPT4H1 VIM
Entrez ID		6827	9124
HPRD ID		16026	09326
Ensembl ID		ENSG00000213246	ENSG00000107438
Uniprot IDs		P63272	O00151 V9HW92
PDB IDs		3H7H 5OIK 6GMH 6GML 6TED 7OKY 7UND 7YCX 8A3Y 8P4C 8P4D 8P4F 8UHA 8UHD 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N 9J0O 9J0P	1X62 2PKT
Enriched GO Terms of Interacting Partners?		Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Positive Regulation Of Defense Response ATP-dependent Activity, Acting On DNA Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Immune System Process Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Lysosome Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Cell Activation Epigenetic Regulation Of Gene Expression Endothelial Microparticle Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Defense Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Chromatin Organization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Calcium-mediated Signaling Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DSIF Complex Small-subunit Processome Assembly DNA End Binding	Pseudopodium Muscle Cell Development Integrin Binding Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Cortical Actin Cytoskeleton Bergmann Glial Cell Differentiation Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Cell Development Astrocyte Development Z Disc Transmembrane Transporter Binding Focal Adhesion Assembly Astrocyte Differentiation Organelle Organization Actin Filament Binding Positive Regulation Of Ion Transmembrane Transporter Activity Focal Adhesion Cell Junction Positive Regulation Of Transporter Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell-substrate Junction Organization Cell-substrate Junction Assembly Cardiac Cell Development Actin Filament Uncapping Cardiac Muscle Cell Development Intermediate Filament Cytoskeleton Superior Vena Cava Morphogenesis Subthalamic Nucleus Development Negative Regulation Of Eosinophil Extravasation Histone H2AS1 Kinase Activity CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Activity Autophagosome Maturation Acylglycerol Kinase Activity Autophagosome Membrane Sarcomere Mitophagy Positive Regulation Of Biosynthetic Process Cytoskeleton Organization Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Postsynapse Titin Z Domain Binding Glial Cell Development Left Lung Morphogenesis Prolactin Secreting Cell Differentiation Cell Proliferation Involved In Outflow Tract Morphogenesis Pulmonary Vein Morphogenesis Septin Cytoskeleton
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