STX5 and NSFL1C

Number of citations of the paper that reports this interaction (PubMedID 12473691)
32

Data Source:
HPRD (in vitro)

		STX5	NSFL1C
Description		syntaxin 5	NSFL1 cofactor
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane SNARE Complex Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Bounding Membrane Of Organelle	Nucleus Chromosome Cytoplasm Golgi Apparatus Golgi Stack Centrosome Cytosol Cytoskeleton VCP-NSFL1C Complex
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Cadherin Binding	Protein Binding Lipid Binding Ubiquitin Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle Fusion Vesicle-mediated Transport Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Vesicle Docking Golgi Disassembly Regulation Of Golgi Organization	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Ubiquitin-dependent Protein Catabolic Process Golgi Organization Nuclear Membrane Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic RHOA GTPase cycle RHOC GTPase cycle RHOG GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	RHOH GTPase cycle
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		48 interacting genes: AARD APLP1 AQP6 BAG6 BET1 COPS6 CRB3 CREB3L3 DRC12 EBP FAM209A GOSR1 GOSR2 GPANK1 GPR152 HAP1 HSD17B13 IMMT JAGN1 KASH5 LMNA LNX1 LRIF1 LRRC4C MAGEA6 MTUS1 NAPA NAPB NSFL1C REEP4 RETREG3 SCFD1 SEC22B SNAP23 SNAP25 STING1 STX1A STX2 STX3 STX4 STXBP1 TACC1 TMEM31 TP53 USO1 VAPB VCP VCPIP1	20 interacting genes: ANP32A CDK1 CEBPA DBI FAM32A FASTKD5 GLMN GSK3B LIPE NEDD8 NGLY1 PBK PHAX PRKACA RPL22 SRP14 STX5 TARDBP UBC VCP
Entrez ID		6811	55968
HPRD ID		04426	09425
Ensembl ID		ENSG00000162236	ENSG00000088833
Uniprot IDs		B4DKR0 Q13190	Q53FE8 Q9UNZ2
PDB IDs		3EFO	1SS6 8HRZ
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity Membrane Fusion Membrane Organization SNARE Complex Organelle Membrane Fusion Organelle Fusion Vesicle Fusion Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization SNARE Binding Vesicle-mediated Transport Intracellular Transport Cellular Localization Vesicle Organization Organelle Localization By Membrane Tethering Membrane Docking Organelle Localization Vesicle Docking Organelle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intracellular Protein Transport Intracellular Protein Localization Golgi Vesicle Transport Exocytosis Regulation Of Synaptic Vesicle Priming Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptic Vesicle Priming Syntaxin Binding Endoplasmic Reticulum Endoplasmic Reticulum Organization Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutamatergic Synapse Positive Regulation Of Synaptic Transmission Vesicle Fusion To Plasma Membrane SNARE Complex Assembly Specific Granule VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Neurotransmitter Transport Synaptic Vesicle Membrane Organization Secretion Membrane Membrane Assembly Secretory Granule Localization Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Endoplasmic Reticulum Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex	Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleocytoplasmic Transport Ubiquitin Protein Ligase Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Intracellular Transport Golgi Disassembly Regulation Of Intracellular Protein Transport RNA Binding Modification-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Organelle Disassembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Metabolic Process Protein Tag Activity Positive Regulation Of Protein Transport Regulation Of Intracellular Transport Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Intracellular Signaling Cassette Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Glutamatergic Synapse Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Catabolic Process Protein Serine Kinase Activity Protein Phosphorylation Macromolecule Metabolic Process Nucleus Regulation Of Osteoblast Differentiation Regulation Of Primary Metabolic Process Regulation Of Protein Localization To Nucleus Negative Regulation Of Smoothened Signaling Pathway Regulation Of Protein Export From Nucleus Phosphorylation Catabolic Process Positive Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
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