STX1A and TNF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STX1A	TNF
Description		syntaxin 1A	tumor necrosis factor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Membrane Secretory Granule Axon Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Actomyosin Presynaptic Membrane Neuron Projection Synapse Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein-containing Complex Neuronal Cell Body Membrane Raft Recycling Endosome
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein-macromolecule Adaptor Activity Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Calcium-dependent Protein Binding	Transcription Cis-regulatory Region Binding Protease Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity Identical Protein Binding Receptor Ligand Activity
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Vesicle-mediated Transport Protein Sumoylation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Hormone Secretion Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Excitatory Postsynaptic Potential	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Microglial Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of L-glutamate Import Across Plasma Membrane Macrophage Activation Involved In Immune Response Chronic Inflammatory Response To Antigenic Stimulus Regulation Of Immunoglobulin Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Skeletal Muscle Contraction Negative Regulation Of Systemic Arterial Blood Pressure Glucose Metabolic Process Defense Response Inflammatory Response Immune Response Humoral Immune Response JNK Cascade Cell Surface Receptor Signaling Pathway Via JAK-STAT Circadian Rhythm Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Virus Response To Bacterium Response To Salt Stress Response To Fructose Animal Organ Morphogenesis Negative Regulation Of Heart Rate Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Response To Activity Regulation Of Metabolic Process Calcium-mediated Signaling Extracellular Matrix Organization Osteoclast Differentiation Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Defense Response Positive Regulation Of Fever Generation Negative Regulation Of Myelination Response To Nutrient Levels Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Positive Regulation Of Fractalkine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Heterotypic Cell-cell Adhesion Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Amide Metabolic Process Response To Isolation Stress Response To Macrophage Colony-stimulating Factor Non-canonical NF-kappaB Signal Transduction Regulation Of Cell Population Proliferation Vasodilation Defense Response To Bacterium Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Viral Genome Replication Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Action Potential Positive Regulation Of Cell Adhesion Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation By Iron Negative Regulation Of D-glucose Import Positive Regulation Of JNK Cascade Astrocyte Activation Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Protein Secretion Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of Neurogenesis Regulation Of Developmental Process Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Regulation Of Synapse Organization Defense Response To Gram-positive Bacterium Cognition Leukocyte Migration Leukocyte Tethering Or Rolling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Transport Regulation Of Multicellular Organismal Process Response To Glucocorticoid Positive Regulation Of Hair Follicle Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Vitamin D Biosynthetic Process Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Retinoic Acid Cellular Response To Nicotine Cellular Response To Type II Interferon Cellular Response To Ionizing Radiation Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Podosome Assembly Endothelial Cell Apoptotic Process Protein Localization To Plasma Membrane Negative Regulation Of Oxidative Phosphorylation Inflammatory Response To Wounding Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Response To Toxic Substance Liver Regeneration Necroptotic Signaling Pathway Negative Regulation Of Bile Acid Secretion Antiviral Innate Immune Response Response To Gram-negative Bacterium Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Interleukin-33 Production Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Amyloid-beta Formation Response To L-glutamate Positive Regulation Of Neutrophil Activation Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Protein Localization Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of Membrane Lipid Metabolic Process Response To 3,3',5-triiodo-L-thyronine Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Hepatocyte Proliferation Regulation Of Endothelial Cell Apoptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (botC) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea	Transcriptional regulation of white adipocyte differentiation TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs			Etanercept Adalimumab Infliximab Chloroquine Epinephrine Pseudoephedrine Clenbuterol Pranlukast Amrinone Trichostatin A Afelimomab YSIL6 SD118 PN0621 OMS-103HP Talmapimod VX-702 Atiprimod CRx-139 CYT007-TNFQb Andrographolide Ethyl pyruvate AME-527 PR-104 Plinabulin Dexanabinol Onercept Golimumab Certolizumab pegol Pomalidomide Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Bryostatin 1 Binimetinib Dilmapimod Glycyrrhizic acid
Diseases			Graft-versus-host disease Systemic lupus erythematosus Allograft rejection Asthma
GWAS		Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Triglyceride levels ( 32203549)	AIDS progression ( 19115949) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cervical cancer ( 28806749) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Neonatal lupus ( 20662065) Psychosis (atypical) ( 24132900) Pulse pressure ( 30578418) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		169 interacting genes: AARD ABCC9 ABI3 AGTRAP AIG1 ANKRD46 AOC3 APBA1 APOL2 APOL3 AQP3 ARL13B ARLN ATP4B ATP6V1B1 BET1 BLOC1S6 BNIP1 BTN2A2 C1GALT1 CACNA1D CCSER2 CD81 CDC37 CDK5 CFTR CLEC1A CLN6 CMTM7 CPLX1 CSNK2A1 CSNK2A2 CXCL16 CYB5B DAPK1 DDX49 DSCR9 DYRK1A EBAG9 EMD ERG28 ETNK2 FAM3C GIMAP1 GIMAP5 GOLM2 GOSR2 GPM6B HMOX1 JAGN1 KCNB1 KIFC3 MAL MALL MIP MMGT1 NAPA NAPB NINJ2 NKG7 NRM NSF PGAP2 PLN PLP1 PLPP4 PLPP6 PNLIPRP1 PSMA3 RAB27A RAB3IL1 RIMS1 RMDN2 RNF4 RTP2 SCNN1A SCNN1B SCNN1G SDCBP SEC22A SEC22B SEPTIN2 SEPTIN5 SERP1 SERP2 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SMIM1 SMIM3 SNAP23 SNAP25 SNAP29 SNAP47 SNORC SNPH STRIT1 STX10 STX11 STX12 STX16 STX2 STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TCEANC TMEM100 TMEM120A TMEM128 TMEM14C TMEM222 TMEM254 TMEM41A TMEM60 TNF TRAF3IP3 TRDMT1 TSGA10IP TSNARE1 TXLNA TXLNB UBE2I UBTFL1 UNC13B UPK1B USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VIM VMA12 VPS11 VPS16 VPS18 VSTM4 VTI1B ZFPL1 ZNF12 ZNF136 ZNF250 ZNF440 ZNF441 ZNF479 ZNF490 ZNF557 ZNF696 ZNF707 ZNF785 ZNF835	72 interacting genes: ADAM17 ADAM9 AQP3 BCL2L13 BGN BIRC2 BTNL9 C10orf67 C2 CCDC107 CCDC70 CLDN7 CLEC10A CREB3L1 CSF1 CYB5R3 DCN FAM209A FFAR2 FNDC9 FYN HNRNPD IFNG IKBKG KASH5 KCNC4 LMNA LRRC25 LRRTM2 LYN MMP14 MMP17 MOB1B MRM3 NFKBIA PAGE1 PANX1 PDIK1L PILRB PIP4P2 PLEKHO1 POU2F1 PPP1R11 PRTN3 RBCK1 RC3H1 RIPK1 RNF19B RNF31 S100A11 S100A12 S100A13 SEC61A1 SGCB SHARPIN SLC14A2 SLC30A4 SSMEM1 STOM STX1A TAPBP TMPRSS2 TNFRSF1A TNFRSF1B TNXB TRAF2 TSG101 VSIR YWHAQ ZCCHC12 ZFP36 ZNG1A
Entrez ID		6804	7124
HPRD ID		01721	01855
Ensembl ID		ENSG00000106089	ENSG00000232810
Uniprot IDs		A0A0C4DFZ1 A8MZ54 Q16623 Q75ME0	P01375 Q5STB3
PDB IDs			1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 4TWT 4Y6O 5M2I 5M2J 5M2M 5MU8 5TSW 5UUI 5WUX 5YOY 6OOY 6OOZ 6OP0 6RMJ 6X81 6X82 6X83 6X85 6X86 7ASY 7AT7 7ATB 7JRA 7KP9 7KPA 7KPB 7QLF 7TA3 7TA6 8Z8M
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Membrane Fusion Organelle Localization By Membrane Tethering Organelle Membrane Fusion Syntaxin Binding Vesicle Fusion Membrane Docking Vesicle Docking Organelle Fusion SNARE Binding Vesicle Organization Membrane Organization Vesicle-mediated Transport Exocytosis Secretion By Cell Membrane Syntaxin-1 Binding Secretion Establishment Of Localization In Cell Establishment Of Protein Localization Organelle Localization Protein Transport Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Endomembrane System Cellular Localization Intracellular Protein Localization SNARE Complex Assembly Neurotransmitter Transport Positive Regulation Of Exocytosis Regulated Exocytosis Regulation Of Secretion By Cell Calcium-ion Regulated Exocytosis Synaptic Vesicle Priming Regulation Of Regulated Secretory Pathway Regulation Of Secretion Intracellular Protein Transport Intracellular Transport Golgi Vesicle Transport Signal Release Synaptic Vesicle Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Presynapse Regulation Of Transport Vesicle-mediated Transport In Synapse Chloride Channel Inhibitor Activity	Tumor Necrosis Factor Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Immune System Process Response To External Biotic Stimulus Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex LUBAC Complex Defense Response Protein Binding Negative Regulation Of Necroptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Inflammatory Response Activation Of Immune Response Negative Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-activating Signaling Pathway Protein Linear Polyubiquitination Membrane Raft Response To Stress Ubiquitin Binding Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cytokine Production T Cell Receptor Signaling Pathway Identical Protein Binding Regulation Of Immune Response Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Necroptotic Process Immune Response-regulating Signaling Pathway Non-canonical NF-kappaB Signal Transduction CD40 Receptor Complex Response To Other Organism Regulation Of DNA-binding Transcription Factor Activity Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding Regulation Of Programmed Necrotic Cell Death Immune System Process Positive Regulation Of Immune Response Calcium-dependent Protein Binding Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis
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