STAT5B and ETS2

Number of citations of the paper that reports this interaction (PubMedID 10815800)
0

Data Source:
HPRD (in vivo, in vitro)

		STAT5B	ETS2
Description		signal transducer and activator of transcription 5B	ETS proto-oncogene 2, transcription factor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cell Cycle Luteinization Natural Killer Cell Differentiation Natural Killer Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Sex Differentiation Female Pregnancy Lactation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Lymphocyte Differentiation Regulation Of Cell Adhesion B Cell Differentiation Erythrocyte Differentiation Regulation Of Epithelial Cell Differentiation Response To Estradiol Positive Regulation Of Interleukin-2 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Erythropoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Population Proliferation Natural Killer Cell Mediated Cytotoxicity Progesterone Metabolic Process Gamma-delta T Cell Differentiation T Cell Homeostasis Response To Peptide Hormone Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Activated T Cell Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Mast Cell Migration Regulation Of Hemopoiesis	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation
Pathways		Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Growth hormone receptor signaling	Oncogene Induced Senescence
Drugs		Dasatinib
Diseases		Growth hormone insensitivity with immunodeficiency
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 34103634 31361310) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233 27569725) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Paracentral lobule volume ( 31530798) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) Central corneal thickness ( 32528159) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) TPE interval (response to exercise) ( 32386560)
Interacting Genes		63 interacting genes: AFTPH APP CBL CBR1 CD247 CDKN1A CHAF1A CPAP CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 HNRNPA2B1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT LGALS14 LMO4 MAPK1 MED25 NCOR2 NMI NR3C1 PDGFRA PDGFRB PIK3R3 POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA RBBP4 SERTAD1 SHC1 SRC STAC STAP2 STAT1 STAT3 STAT5A SUOX TEK TFG TSSK3 USP2 WEE2-AS1	39 interacting genes: CDK10 CLU COP1 CREBBP DAD1 DMXL2 EGLN2 EP300 ERG ETS1 FOCAD FOS GABRD GATA3 GTF3C4 HMGN1 JUN NCOR1 NDRG1 NDUFB5 NR3C1 POU5F1 PPME1 RPL15 SERPINE2 SLC71A2 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 TERF2IP TTC3 UBC USP7 ZBTB44 ZFYVE9 ZMYND11
Entrez ID		6777	2114
HPRD ID		05037	01263
Ensembl ID		ENSG00000173757	ENSG00000157557
Uniprot IDs		P51692	P15036
PDB IDs		6MBW 6MBZ	4BQA 4MHV
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Receptor Signaling Pathway Via JAK-STAT Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Response To Growth Factor Animal Organ Development Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Via STAT Peptidyl-tyrosine Phosphorylation Regulation Of Locomotion Regulation Of Immune System Process Regulation Of Signal Transduction Regulation Of Cell Migration Positive Regulation Of Metabolic Process Positive Regulation Of Cell Motility Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Protein Tyrosine Kinase Activity Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Cell Differentiation Phosphorylation Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Activation Positive Regulation Of Phosphate Metabolic Process Regulation Of Signaling Regulation Of Cell Communication	Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Chromatin Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding DNA Binding Myeloid Cell Differentiation Chromatin Organization Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Histone H3K27 Acetyltransferase Activity Positive Regulation Of Leukocyte Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Pro-T Cell Differentiation Mononuclear Cell Differentiation Host-mediated Activation Of Viral Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Activation Response To Stress Myeloid Leukocyte Activation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell-cell Adhesion DNA-binding Transcription Factor Activity Transcription Regulator Complex Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Leukocyte Differentiation
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