STAC and RNF208

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STAC	RNF208
Description		SH3 and cysteine rich domain	ring finger protein 208
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane T-tubule Sarcolemma	Nucleoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Skeletal Muscle Contraction Muscle Contraction Signal Transduction Cellular Response To Heat Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cation Channel Activity	Protein Ubiquitination Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS		Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 29273806) Brooding (response to stress) ( 30886212) Celiac disease ( 23936387) Erectile dysfunction in type 1 diabetes ( 22704111) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 31537649) Metabolite levels ( 23823483) Smoking behaviour (maximum cigarettes in a 24 hour period) ( 29532581)
Interacting Genes		22 interacting genes: APP FBXO25 GOLGA2 KANK2 KIAA1958 LIMD1 LMNA LRRK2 LZTS2 MEOX2 NBPF19 NCKIPSD NEDD4L NOTCH2NLA PAX5 PAX6 PJA1 POU6F2 RNF208 STAT5B TRIP6 TRMO	18 interacting genes: BUD31 CREB5 DAZAP2 GRB2 HOXA1 KRTAP15-1 KRTAP26-1 LITAF OXER1 PIN1 RNF38 RPIA SH3RF1 STAC TRIM32 UBQLN1 UBQLN2 USP54
Entrez ID		6769	727800
HPRD ID		11890
Ensembl ID		ENSG00000144681	ENSG00000212864
Uniprot IDs		B4DR96 B4DZ13 E9PEA7 Q8WUK8 Q99469	Q9H0X6
PDB IDs		2DL4 6B25
Enriched GO Terms of Interacting Partners?		Cellular Response To Manganese Ion	Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Autophagosome Positive Regulation Of Metabolic Process Autophagosome Organization Autophagosome Assembly Positive Regulation Of ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process WW Domain Binding Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Semicircular Canal Formation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cis-trans Isomerase Activity Ribose-5-phosphate Isomerase Activity Vacuole Organization Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Regulation Of Proteolysis Regulation Of Macroautophagy Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding Positive Regulation Of Protein Metabolic Process Regulation Of Autophagosome Assembly Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Grb2-EGFR Complex Abducens Nerve Formation Optokinetic Behavior Cytoplasmic Side Of Late Endosome Membrane Protein Localization To Phagocytic Vesicle Regulation Of Vacuole Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Protein Polymerization Transcription Coactivator Activity D-ribose Metabolic Process
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