SRP68 and SRP72

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		SRP68	SRP72
Description		signal recognition particle 68	signal recognition particle 72
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Ribosome Focal Adhesion Signal Recognition Particle Ribonucleoprotein Complex	Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Signal Recognition Particle Ribonucleoprotein Complex
	Molecular Function	RNA Binding Signal Recognition Particle Binding Protein Binding 7S RNA Binding Protein Domain Specific Binding Endoplasmic Reticulum Signal Peptide Binding Ribosome Binding	RNA Binding Signal Recognition Particle Binding Protein Binding 7S RNA Binding TPR Domain Binding Ribosome Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane Response To Xenobiotic Stimulus	SRP-dependent Cotranslational Protein Targeting To Membrane
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378)
Interacting Genes		10 interacting genes: ABI1 CEBPA CFTR OGT RBFOX2 RNF10 SRP72 SUMO2 UBQLN2 WEE2-AS1	14 interacting genes: CASP3 CASP6 CDC42 CEBPA EDN2 FCHSD2 HSPB1 KDR OGT PYGM SKIL SRP68 SULT2B1 TULP3
Entrez ID		6730	6731
HPRD ID		05331	03671
Ensembl ID		ENSG00000167881	ENSG00000174780
Uniprot IDs		Q9UHB9	O76094 V9HWK0
PDB IDs		4P3E 4P3F 5M72 5M73 5WRV 7NFX 7QWQ 8QVW 8QVX	5M72 5M73 5WRV 5WRW 7NFX 8QVW 8QVX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin DNA Binding Response To Vitamin B2 C/EBP Complex Regulation Of Protein Metabolic Process Positive Regulation Of Anion Channel Activity Negative Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Monoatomic Anion Transport Protein O-acetylglucosaminyltransferase Activity Sterol Metabolic Process Cholesterol Metabolic Process White Fat Cell Proliferation Positive Regulation Of Enamel Mineralization Negative Regulation Of Clathrin-dependent Endocytosis Pre-mRNA 5'-splice Site Binding Positive Regulation Of Macromolecule Metabolic Process Response To Phenylpropanoid Positive Regulation Of Catabolic Process Response To Nutrient Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization	Cellular Response To Staurosporine Pyroptotic Inflammatory Response Epithelial Cell Differentiation Multicellular Organismal-level Homeostasis Endothelin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Protein-containing Complex Binding Epithelial Cell Maturation Positive Regulation Of Chemotaxis Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Necroptotic Process Embryonic Organ Development Cellular Response To Alkaloid Signal Transduction Intrinsic Apoptotic Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Homeostatic Process Protein Processing Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Programmed Cell Death Cytoplasm Epithelial Cell Apoptotic Process Inflammatory Response Cellular Developmental Process Response To Cytokine Positive Regulation Of Organelle Organization Regulation Of Cell Migration Macrophage Differentiation Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell Tip Growth Hormonal Regulation Of The Force Of Heart Contraction Regulation Of Chemotaxis Lung Alveolus Development Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Stereocilium Shaft Epithelium Development Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Response To Peptide Regulation Of Cell Motility Vasculature Development
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