SPRR2A and PSMG1

		SPRR2A	PSMG1
Description		small proline rich protein 2A	proteasome assembly chaperone 1
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Cytosol Transport Vesicle Secretory Granule Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Protein Folding Chaperone Complex
	Molecular Function	Protein Binding Lipid Binding	Protein Binding Molecular Adaptor Activity Proteasome Binding
	Biological Process	Antibacterial Humoral Response Defense Response To Bacterium Host-mediated Modulation Of Intestinal Microbiota Composition Defense Response To Gram-positive Bacterium	Cerebellar Granule Cell Precursor Proliferation Proteasome Assembly Chaperone-mediated Protein Complex Assembly Proteasome Core Complex Assembly
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Proteasome assembly Proteasome assembly
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Alanine aminotransferase levels ( 33547301) Ankylosing spondylitis ( 20062062) C-reactive protein levels ( 21300955) Daytime nap ( 33568662) Daytime sleep phenotypes ( 27126917) Eye morphology ( 29921221) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Inflammatory bowel disease ( 18758464) Pediatric autoimmune diseases ( 26301688) Primary sclerosing cholangitis ( 27992413 23603763) Serum alkaline phosphatase levels ( 33547301) Takayasu arteritis ( 23830517) Triglyceride levels ( 32203549) Ulcerative colitis ( 20228799)
Interacting Genes		11 interacting genes: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 PSMG1 YES1	15 interacting genes: BRCA1 CEBPA CSDE1 GATD3 IDS PRKAR1A PRKAR1B PSMG2 RRP1 SNRNP70 SPRR2A SPTAN1 UBE2A UBE2G2 YME1L1
Entrez ID		6700	8624
HPRD ID		01649	05598
Ensembl ID		ENSG00000241794	ENSG00000183527
Uniprot IDs		P35326	O95456
PDB IDs			8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8YIX 8YIY 8YIZ
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Cytosol Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Protein Kinase Activity Regulation Of Immune Response Response To Transforming Growth Factor Beta Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Motility Actin Filament Immune Response-regulating Cell Surface Receptor Signaling Pathway Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Immune Response-activating Signaling Pathway Proline-rich Region Binding Regulation Of Actin Filament-based Process Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Cellular Response To Oxygen-containing Compound Response To Reactive Oxygen Species Ephrin Receptor Binding Cell Migration Cortical Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Dendritic Spine Organization Positive Regulation Of Cytoskeleton Organization Protein Modification Process Regulation Of Cytoskeleton Organization Negative Regulation Of Immune Response Regulation Of Biological Quality Intracellular Protein Localization SH2 Domain Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Organization Postsynapse Organization Postsynapse Leukocyte Migration Positive Regulation Of Locomotion	CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Cellular Response To Tumor Necrosis Factor Protein Kinase A Catalytic Subunit Binding Response To Tumor Necrosis Factor CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Postreplication Repair Cellular Response To Cytokine Stimulus Ubiquitin Conjugating Enzyme Activity Regulation Of CAMP/PKA Signal Transduction Multivesicular Body Ciliary Base RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Iduronate-2-sulfatase Activity
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