SPRR2A

Description		small proline rich protein 2A
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Cytosol Transport Vesicle Secretory Granule Cytoplasmic Vesicle
	Molecular Function	Protein Binding Lipid Binding
	Biological Process	Antibacterial Humoral Response Defense Response To Bacterium Host-mediated Modulation Of Intestinal Microbiota Composition Defense Response To Gram-positive Bacterium
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Novel Interacting Genes		11 novel interacting genes: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 PSMG1 YES1
Interacting Genes		11 interacting genes: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 PSMG1 YES1
Entrez ID		6700
HPRD ID		01649
Ensembl ID		ENSG00000241794
Uniprot IDs		P35326
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Cytosol Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Protein Kinase Activity Regulation Of Immune Response Response To Transforming Growth Factor Beta Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Motility Actin Filament Immune Response-regulating Cell Surface Receptor Signaling Pathway Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Immune Response-activating Signaling Pathway Proline-rich Region Binding Regulation Of Actin Filament-based Process Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Cellular Response To Oxygen-containing Compound Response To Reactive Oxygen Species Ephrin Receptor Binding Cell Migration Cortical Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Dendritic Spine Organization Positive Regulation Of Cytoskeleton Organization Protein Modification Process Regulation Of Cytoskeleton Organization Negative Regulation Of Immune Response Regulation Of Biological Quality Intracellular Protein Localization SH2 Domain Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Organization Postsynapse Organization Postsynapse Leukocyte Migration Positive Regulation Of Locomotion
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