SPINT1 and TMEM109

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPINT1	TMEM109
Description		serine peptidase inhibitor, Kunitz type 1	transmembrane protein 109
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane Extracellular Exosome	Nucleus Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Protein Binding Voltage-gated Monoatomic Cation Channel Activity
	Biological Process	Neural Tube Closure Embryonic Placenta Development Epidermis Development Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Epithelium Development Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Programmed Cell Death Cellular Response To Gamma Radiation Monoatomic Cation Transmembrane Transport
Pathways		MET Receptor Activation Signaling by MST1
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5	16 interacting genes: AQP2 AQP9 ERGIC3 GOLM1 GPX8 LMNA MGST3 MTIF3 PDZK1IP1 RNF170 SAR1A SLC18A2 SPINT1 STOM TMEM52B TMEM80
Entrez ID		6692	79073
HPRD ID		05494	14687
Ensembl ID		ENSG00000166145	ENSG00000110108
Uniprot IDs		O43278	Q9BVC6
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wound Healing Cell Surface Positive Regulation Of Monocyte Chemotactic Protein-1 Production Basal Part Of Cell	Polyol Transmembrane Transport Glycerol Transmembrane Transport Amine Transport Water Channel Activity Membrane Glutathione Peroxidase Activity Water Transport Organic Hydroxy Compound Transport Fluid Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Channel Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Serotonin Secretion By Mast Cell Somato-dendritic Dopamine Secretion Transport Vesicle Membrane Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Aminergic Neurotransmitter Loading Into Synaptic Vesicle Retrograde Transporter Complex, Golgi To ER Amino Acid Sensor Activity Mitochondrial Translational Initiation Cellular Response To Mercury Ion Cellular Response To Water Deprivation Purine Nucleobase Transmembrane Transporter Activity Urea Channel Activity Hydrogen Peroxide Channel Activity Cellular Oxidant Detoxification Histamine Uptake Serotonin:sodium:chloride Symporter Activity
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