SNAPC4 and SNAPC2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		SNAPC4	SNAPC2
Description		small nuclear RNA activating complex polypeptide 4	small nuclear RNA activating complex polypeptide 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm SnRNA-activating Protein Complex	Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity	RNA Polymerase II General Transcription Initiation Factor Activity
	Biological Process	SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III	Transcription By RNA Polymerase II Transcription By RNA Polymerase III SnRNA Transcription
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS		Crohn's disease ( 21102463 22936669 28067908) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Joint damage in rheumatoid arthritis ( 26498133) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Neutrophil percentage of white cells ( 32888494) Takayasu arteritis ( 33308445) Ulcerative colitis ( 21297633 28067908)	HDL cholesterol ( 26160806) LDL cholesterol ( 26160806)
Interacting Genes		8 interacting genes: BRF2 HNRNPD MAPK6 POU2F1 SNAPC1 SNAPC2 SNAPC5 TBP	4 interacting genes: MBD1 RFX2 SNAPC4 TBP
Entrez ID		6621	6618
HPRD ID		04146	05464
Ensembl ID		ENSG00000165684	ENSG00000104976
Uniprot IDs		Q5SXM2	Q13487
PDB IDs		7XUR 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		RNA Polymerase II General Transcription Initiation Factor Activity Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity SnRNA Transcription Transcription By RNA Polymerase II DNA-templated Transcription SnRNA Metabolic Process DNA-templated Transcription Initiation SnRNA Transcription By RNA Polymerase III RNA Metabolic Process Nucleoplasm SnRNA Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Nucleus Transcription Preinitiation Complex Assembly Hepatocyte Dedifferentiation Cellular Response To Putrescine Macromolecule Metabolic Process Circadian Regulation Of Translation Septin Cytoskeleton SnRNA-activating Protein Complex Transcription Factor TFIIIB Complex TFIIB-class Transcription Factor Binding Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Response To Rapamycin Cell Dedifferentiation RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding Pronucleus Protein-DNA Complex Assembly Transcription Initiation At RNA Polymerase III Promoter Male Pronucleus Aryl Hydrocarbon Receptor Binding Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Female Pronucleus CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Female Germ Cell Nucleus Transcription Preinitiation Complex Regulation Of Telomere Capping	RNA Polymerase III General Transcription Initiation Factor Activity Transcription By RNA Polymerase II Transcription By RNA Polymerase III RNA Polymerase II General Transcription Initiation Factor Activity DNA-templated Transcription DNA Binding Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SnRNA-activating Protein Complex Double-stranded Methylated DNA Binding RNA Polymerase Transcription Factor SL1 Complex TFIIB-class Transcription Factor Binding Transcription Factor TFIIA Complex Unmethylated CpG Binding Macromolecule Biosynthetic Process RNA Metabolic Process SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding Male Pronucleus Aryl Hydrocarbon Receptor Binding Pronucleus RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Female Pronucleus Female Germ Cell Nucleus SnRNA Transcription Core Promoter Sequence-specific DNA Binding Male Gamete Generation Spermatogenesis RNA Polymerase II Core Promoter Sequence-specific DNA Binding Gamete Generation Nucleic Acid Metabolic Process Methyl-CpG Binding Acrosome Assembly Transcription Factor TFIID Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process SnRNA Metabolic Process RNA Polymerase II Preinitiation Complex Assembly Male Germ Cell Nucleus Constitutive Heterochromatin Formation MRNA Transcription Euchromatin Transcription Preinitiation Complex Assembly Developmental Process Involved In Reproduction
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