SNCB and GRK5

Number of citations of the paper that reports this interaction (PubMedID 10852916)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		SNCB	GRK5
Description		synuclein beta	G protein-coupled receptor kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Inclusion Body Neuronal Cell Body Axon Terminus Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Nuclear Membrane
	Molecular Function	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Transition Metal Ion Binding Cuprous Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity
	Biological Process	Chemical Synaptic Transmission Dopamine Metabolic Process Negative Regulation Of Neuron Apoptotic Process Synaptic Vesicle Endocytosis Synapse Organization Neuron Apoptotic Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle
Pathways		MTF1 activates gene expression	G alpha (q) signalling events G alpha (s) signalling events
Drugs
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
GWAS			Appendicular lean mass ( 33097823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 30060048) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Thymus and reactivation regulated chemokine levels ( 33227023) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31676865 31420334) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		13 interacting genes: AKT1 APP CENPT GRK1 GRK5 GRK6 HSPA1A LNX1 MORN4 PLK1 PLK3 SEPTIN4 SNCA	19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		6620	2869
HPRD ID		03980	02926
Ensembl ID		ENSG00000074317	ENSG00000198873
Uniprot IDs		G4Y815 G4Y816 Q16143	P34947
PDB IDs			4TNB 4TND 6PJX 8UAP 8UAQ 9BRE 9BRG 9BRH 9BRI 9BRJ
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Apoptotic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Programmed Cell Death Kinase Activity Beta-adrenergic Receptor Kinase Activity Protein Phosphorylation Regulation Of Proteolysis Phosphorylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Nucleotide Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Localization Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Chaperone-mediated Autophagy ATP Binding Apoptotic Process Negative Regulation Of Apoptotic Process Postsynapse Phosphate-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Post-translational Protein Modification Programmed Cell Death Cell Death Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Cycle Inclusion Body Protein Autophosphorylation Transferase Activity Regulation Of Neurotransmitter Uptake Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Cellular Response To Copper Ion Regulation Of Mitotic Spindle Assembly	Regulation Of Vasoconstriction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction G Protein-coupled Receptor Activity Regulation Of System Process G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Circulatory System Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cytosolic Calcium Ion Concentration System Process Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Transport Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of Muscle Contraction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Blood Pressure Vasopressin Receptor Activity Regulation Of Cell Communication Cuprous Ion Binding Presynaptic Endocytosis Regulation Of Muscle System Process Smooth Muscle Contraction Regulation Of Signaling Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Plasma Membrane Regulation Of Secretion Vesicle-mediated Transport In Synapse Endocytosis Sperm Ejaculation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endosome Synaptic Vesicle Endocytosis Signal Transduction Membrane Chemical Synaptic Transmission Sperm Midpiece Positive Regulation Of Small Molecule Metabolic Process Regulation Of Secretion By Cell Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Axon Terminus Aggressive Behavior
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