SNAP25 and OSBPL5

Number of citations of the paper that reports this interaction (PubMedID 32734583)
70

Data Source:
BioGRID (protein complementation assay)

		SNAP25	OSBPL5
Description		synaptosome associated protein 25	oxysterol binding protein like 5
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding	Phosphatidylserine Binding Phospholipid Transporter Activity Oxysterol Binding Lipid Binding Cholesterol Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylserine Transfer Activity
	Biological Process	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis	Lipid Transport Golgi To Plasma Membrane Transport Cholesterol Metabolic Process Phospholipid Transport Cholesterol Transport Phosphatidylserine Acyl-chain Remodeling Intermembrane Lipid Transfer
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	Acyl chain remodelling of PS
Drugs		Botulinum toxin type A Letibotulinumtoxina
Diseases
GWAS		Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)	Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Cerebral microbleeds (lobar) ( 32913026) Cisplatin-induced ototoxicity ( 28039263) Malaria ( 31844061)
Interacting Genes		45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177	4 interacting genes: APP HGS SNAP25 SNCA
Entrez ID		6616	114879
HPRD ID		02637	09475
Ensembl ID		ENSG00000132639	ENSG00000021762
Uniprot IDs		P60880	A8KAD5 Q9H0X9
PDB IDs		1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV
Enriched GO Terms of Interacting Partners?		SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport	Growth Cone Positive Regulation Of Synaptic Transmission Import Into Cell Locomotory Behavior Synaptic Vesicle Priming Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Neurotransmitter Uptake Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Copper Ion Chemical Synaptic Transmission Amyloid Fibril Formation Vesicle-mediated Transport Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Neurotransmitter Uptake Trans-synaptic Signaling Synaptic Signaling Neurotransmitter Secretion Regulation Of Protein Catabolic Process Axon Long-term Synaptic Potentiation Establishment Of Localization In Cell Regulation Of Neuronal Synaptic Plasticity Endocytosis Regulation Of Transport Modulation Of Chemical Synaptic Transmission Macrophage Activation Lysosome Positive Regulation Of Reactive Oxygen Species Metabolic Process SNARE Binding Receptor Internalization Regulation Of Vesicle-mediated Transport Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Adult Locomotory Behavior Regulation Of Secretion By Cell Positive Regulation Of Exocytosis Amyloid-beta Complex Cell-cell Signaling Growth Cone Lamellipodium Cell Communication Associative Learning Regulation Of Response To Calcium Ion Amylin Binding
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