SNAI1 and USP29

Number of citations of the paper that reports this interaction (PubMedID 32973332)
0

Data Source:
BioGRID (enzymatic study, pull down)

		SNAI1	USP29
Description		snail family transcriptional repressor 1	ubiquitin specific peptidase 29
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Kinase Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesenchymal Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	G1/S Transition Of Mitotic Cell Cycle Immune System Process Proteolysis Protein Deubiquitination Regulation Of Protein Stability Innate Immune Response Protein Stabilization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Deubiquitination
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription Epithelial-Mesenchymal Transition (EMT) during gastrulation Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Urate levels in lean individuals ( 25811787)
Interacting Genes		49 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CREBBP CTDSP1 CTDSP2 CTDSPL DDB1 EFHC1 EIF3H EXOSC8 FBXO22 FBXO45 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KPNB1 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTA1 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RBX1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIP6 USP29 XRCC3	5 interacting genes: CLSPN CTDSP1 HRAS MAP3K7 SNAI1
Entrez ID		6615	57663
HPRD ID		05025	07163
Ensembl ID		ENSG00000124216	ENSG00000131864
Uniprot IDs		O95863	A1L447 Q9HBJ7
PDB IDs		2Y48 3W5K 3ZMT 4QLI 8BOX 8F59 8FDV 8FJ7
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Signal Transduction Post-translational Protein Modification Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Deubiquitination RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Regulation Of Mitotic Cell Cycle Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphatase Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Telomere Maintenance Via Telomere Trimming Negative Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Mesenchymal Cell Differentiation Protein Polyubiquitination Response To Stress Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Phosphoprotein Phosphatase Activity Cytoplasm Negative Regulation Of Cell Communication	Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Migration Phospholipase C Activator Activity T Cell Receptor Signaling Pathway Regulation Of Primary Metabolic Process Oncogene-induced Cell Senescence Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Motility Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Cycle GTPase Complex MAPK Cascade Negative Regulation Of Vitamin D Biosynthetic Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation I-kappaB Phosphorylation Interleukin-17A-mediated Signaling Pathway Linear Polyubiquitin Binding Signal Transduction In Response To DNA Damage MAP Kinase Kinase Kinase Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Histone Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Negative Regulation Of Mitotic Cell Cycle DNA Secondary Structure Binding Regulation Of Locomotion Positive Regulation Of CGAS/STING Signaling Pathway Interleukin-33-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Ruffle Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process T-helper 1 Type Immune Response Immune Response-activating Signaling Pathway Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Trophoblast Giant Cell Differentiation Heterochromatin Organization Left/right Pattern Formation Cartilage Morphogenesis Regulation Of Vitamin Metabolic Process Positive Regulation Of Phosphate Metabolic Process
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