SMS and LARP7

		SMS	LARP7
Description		spermine synthase	La ribonucleoprotein 7, transcriptional regulator
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytosol 7SK SnRNP Ribonucleoprotein Complex
	Molecular Function	Transferase Activity Spermine Synthase Activity	Nucleic Acid Binding RNA Binding Protein Binding U6 SnRNA Binding 7SK SnRNA Binding
	Biological Process	Methionine Metabolic Process Polyamine Metabolic Process Polyamine Biosynthetic Process Spermine Biosynthetic Process Spermine Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Box C/D Sno(s)RNA 3'-end Processing RNA Processing MRNA Processing Spermatogenesis RNA Splicing Cell Differentiation Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II U6 2'-O-snRNA Methylation
Pathways		Metabolism of polyamines
Drugs		Spermine
Diseases		Snyder-Robinson syndrome
GWAS			Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Dental caries (decayed and filled deciduous teeth) ( 31533690) Meat-related diet ( 32066663) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: CEBPA EZH2 LARP7 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3	90 interacting genes: APP BARD1 BRCA1 CHRNB4 GABRG2 GAR1 JMJD6 LRRK2 MCUB MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OSTC PAPSS1 PPA2 PRPF40A PUF60 RN7SK RRH SMS WEE2-AS1 ZGRF1
Entrez ID		6611	51574
HPRD ID		02115	17095
Ensembl ID		ENSG00000102172	ENSG00000174720
Uniprot IDs		P52788	A0A8I5KUI4 A0A8Q3SHH4 A0A8Q3SHN7 H0YA82 Q4G0J3
PDB IDs		3C6K 3C6M	4WKR 5KNW 6D12 7SLP 7SLQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Intracellular Signaling Cassette Response To Lipid Intracellular Signal Transduction Animal Organ Regeneration MAPK Cascade Toll-like Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Hepatocyte Homeostasis Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity U6 2'-O-snRNA Methylation Nucleoplasm Chromatin DNA Binding Response To Vitamin B2 Positive Regulation Of Defense Response Liver Development C/EBP Complex Cellular Response To Trichostatin A Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Septin Cytoskeleton Protein Kinase Binding Protein Kinase Activity CHOP-C/EBP Complex Positive Regulation Of Developmental Process Regeneration Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Box C/D Sno(s)RNA 3'-end Processing Kinase Activity White Fat Cell Proliferation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Histone H3K27 Methyltransferase Activity Innate Immune Response-activating Signaling Pathway Ribosomal Protein S6 Kinase Activity Calcium-dependent Protein Serine/threonine Kinase Activity SnRNA Modification Response To Phenylpropanoid Protein-containing Complex Pronucleus Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Transferase Activity Methylation	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Gene Expression Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Cytokine Production Negative Regulation Of Vasculature Development Negative Regulation Of Cell Motility Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Cytokine Production Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion
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