SMARCA2 and GCC1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		SMARCA2	GCC1
Description		SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2	GRIP and coiled-coil domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex BBAF Complex GBAF Complex	Golgi Trans Cisterna Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Nucleosome Array Spacer Activity	Protein Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Growth Heterochromatin Formation Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751) Thyroid volume in Hashimoto’s thyroiditis ( 32019955)	Feeling worry ( 29500382) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Medication adherence in chronic diseases ( 25317111) Refractive error ( 32231278) Type 2 diabetes ( 22158537 26818947 30718926)
Interacting Genes		53 interacting genes: ACTL6A ACTL6B ACTN2 ANO10 APC2 AR ARID1B BEND7 BRCA1 CCDC136 CEBPA CEP72 CNTROB CXXC1 DAB2IP DNM2 ESR1 FOXP1 GAPDH GCC1 GFAP H3C1 HSPB1 ITPRID2 KHDRBS1 LAMC1 MDM2 MDM4 MECP2 MPRIP MYB MYC MYO5B NECAB2 NR0B2 NR3C1 NR4A2 NUP62 PHB1 PICK1 PITX1 PPFIA2 PPP1R12C PRPF6 RAP1A SDCBP SIN3B SPAG5 SS18 SUPT4H1 TACC2 TNFAIP1 ZNF821	73 interacting genes: ABI2 ADGRE5 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC33 CCDC85B CEP57 CEP70 COIL CPSF7 CRHR2 DISC1 DNAJA3 DRC4 FAM83A FBF1 FBXO28 FIGNL1 FOSL1 GARIN1A GLI1 GOLGA2 GTF2I HDX HILPDA ICA1L IKBKG ITSN1 KATNAL1 KDM1A KHSRP KIAA0753 KIAA1217 KIF5B LCA5 LZTS2 MCRS1 MED4 MEOX1 MID2 NAB2 NAV1 NECAB2 NINL OIP5 PAK5 PCDHA1 PPP1R18 PPP1R27 PRPF18 RBM28 RUNX1 SMARCA2 SMARCD1 SPOP TFIP11 TLE5 TP53BP2 TRIM29 TRIM50 TSC1 USHBP1 UTP14C XIAP ZC4H2 ZFP90 ZNF276
Entrez ID		6595	79571
HPRD ID		02483	07599
Ensembl ID		ENSG00000080503	ENSG00000179562
Uniprot IDs		B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1	A4D0Z4 Q96CN9
PDB IDs		2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ 7S4E 7Z6L 7Z76 7Z77 7Z78 8G1P 8QJT 9D11 9D12 9E1K 9E30 9E31
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Developmental Process Negative Regulation Of Biosynthetic Process Protein-containing Complex Positive Regulation Of Cell Population Proliferation Organelle Organization Chromatin Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Regulation Of Cell Population Proliferation SWI/SNF Complex Regulation Of MiRNA Transcription Chromatin Remodeling Regulation Of Developmental Process Estrogen Response Element Binding Regulation Of G0 To G1 Transition Cytoskeleton Protein Domain Specific Binding Microtubule Organizing Center Organization Regulation Of MiRNA Metabolic Process Nucleoplasm Brahma Complex NpBAF Complex GBAF Complex	Identical Protein Binding Protein Binding Cytoskeleton Microtubule Centrosome Microtubule Severing Transcription Coactivator Activity Microtubule-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of DNA Repair Microtubule Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process P53 Binding Microtubule Severing ATPase Activity Regulation Of Primary Metabolic Process Lens Fiber Cell Morphogenesis Ciliary Basal Body Regulation Of Cellular Response To Stress Regulation Of Double-strand Break Repair Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Manganese Ion Spindle Pole Cytoplasm Organization Microtubule Cytoskeleton Organization Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Spermatid Development
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