SLC22A1 and LAPTM4A

Number of citations of the paper that reports this interaction (PubMedID 31318583)
0

Data Source:
BioGRID (protein complementation assay)

		SLC22A1	LAPTM4A
Description		solute carrier family 22 member 1	lysosomal protein transmembrane 4 alpha
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Presynapse	Lysosomal Membrane Golgi Apparatus Endomembrane System Membrane Late Endosome Membrane
	Molecular Function	Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity	Protein Binding
	Biological Process	Xenobiotic Metabolic Process Monoatomic Ion Transport Monoatomic Cation Transport Neurotransmitter Transport Serotonin Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Prostaglandin Transport Monoamine Transport Putrescine Transport Spermidine Transport Acetylcholine Transport Dopamine Transport Norepinephrine Transport Thiamine Transport Xenobiotic Transport Epinephrine Transport Serotonin Uptake Norepinephrine Uptake Transmembrane Transport Thiamine Transmembrane Transport Metanephric Proximal Tubule Development Purine-containing Compound Transmembrane Transport Dopamine Uptake Monoatomic Cation Transmembrane Transport Transport Across Blood-brain Barrier (R)-carnitine Transmembrane Transport O-acyl-L-carnitine Transmembrane Transport Spermidine Transmembrane Transport Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport SLC-mediated transport of neurotransmitters SLC-mediated transport of organic cations Ciprofloxacin ADME
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Essential hypertension (time to event) ( 32589924) Gout ( 22179738) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol levels ( 32203549) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 26377243) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Prostate cancer ( 21743057 26034056) Serum metabolite levels ( 33031748 23093944) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 31959995 29545352)	Major depressive disorder ( 21621269) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		30 interacting genes: ALDOA ARID5B CAPN1 CCL2 CD63 CD9 CERS2 CHST12 CLPTM1 CYSTM1 FIS1 FXYD2 GHITM GRM3 KRTCAP2 LAPTM4A LAPTM4B MUC1 OS9 PDZK1IP1 POU2AF1 SERP1 SLC25A11 SMIM24 SMIM3 SPP1 TMBIM4 TMEM147 TMEM179B VAPB	10 interacting genes: FFAR2 GLP1R MTNR1A RRM2 SLC22A1 SLC22A2 TMED8 TRIM55 TRIM63 TUBB3
Entrez ID		6580	9741
HPRD ID		04007	13959
Ensembl ID		ENSG00000175003	ENSG00000068697
Uniprot IDs		O15245	Q15012 Q6IBP4
PDB IDs		8ET6 8ET7 8ET8 8JTS 8JTT 8JTV 8JTW 8JTX 8JTY 8JTZ 8JU0 8SC1 8SC2 8SC3 8SC4 8SC6
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Unfolded Protein Response Multivesicular Body, Internal Vesicle Response To Endoplasmic Reticulum Stress Muscle Organ Morphogenesis Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration	Acetylcholine Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Transmembrane Transporter Activity Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Leukocyte Migration Involved In Inflammatory Response Dopamine Transport Neurotransmitter Reuptake Xenobiotic Transmembrane Transporter Activity Monoamine Transport Neurotransmitter Uptake Purine-containing Compound Transmembrane Transport Vitamin Transport Xenobiotic Transport Glucagon-like Peptide 1 Receptor Activity Basal Plasma Membrane Microtubule G Protein-coupled Receptor Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus (R)-carnitine Transmembrane Transport (R)-carnitine Transmembrane Transporter Activity Organic Cation Transport Transport Across Blood-brain Barrier
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