SLC22A1 and ARID5B

		SLC22A1	ARID5B
Description		solute carrier family 22 member 1	AT-rich interaction domain 5B
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GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Presynapse	Nucleus Nucleoplasm
	Molecular Function	Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Xenobiotic Metabolic Process Monoatomic Ion Transport Monoatomic Cation Transport Neurotransmitter Transport Serotonin Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Prostaglandin Transport Monoamine Transport Putrescine Transport Spermidine Transport Acetylcholine Transport Dopamine Transport Norepinephrine Transport Thiamine Transport Xenobiotic Transport Epinephrine Transport Serotonin Uptake Norepinephrine Uptake Transmembrane Transport Thiamine Transmembrane Transport Metanephric Proximal Tubule Development Purine-containing Compound Transmembrane Transport Dopamine Uptake Monoatomic Cation Transmembrane Transport Transport Across Blood-brain Barrier (R)-carnitine Transmembrane Transport O-acyl-L-carnitine Transmembrane Transport Spermidine Transmembrane Transport Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Cellular Response To Leukemia Inhibitory Factor
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport SLC-mediated transport of neurotransmitters SLC-mediated transport of organic cations Ciprofloxacin ADME	HDMs demethylate histones
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Essential hypertension (time to event) ( 32589924) Gout ( 22179738) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol levels ( 32203549) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 26377243) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Prostate cancer ( 21743057 26034056) Serum metabolite levels ( 33031748 23093944) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 31959995 29545352)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 19684603 19684604 22076464 29348612 33891562 28817678 25310577 23512250) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Automobile speeding propensity ( 30643258) B-cell acute lymphoblastic leukaemia ( 31767839) Blood urea nitrogen levels ( 31152163) Central corneal thickness ( 32528159 31798171 30894546 29760442) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Corneal resistance factor ( 30894546) Corneal structure ( 23291589) Diastolic blood pressure ( 19430483) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Gout ( 32238385) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454 29617998) Intraocular pressure (Goldman correlated) ( 30894546) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Neutrophil percentage of white cells ( 32888494) Plateletcrit ( 27863252 32888494) Reaction time ( 29844566) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 22446963 23143596 24390342 30423114 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum metabolite levels ( 33031748) Serum total protein levels ( 23022100) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 26502338 27399966 33272962 23273568) Tinnitus ( 33742053) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 32499647) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		30 interacting genes: ALDOA ARID5B CAPN1 CCL2 CD63 CD9 CERS2 CHST12 CLPTM1 CYSTM1 FIS1 FXYD2 GHITM GRM3 KRTCAP2 LAPTM4A LAPTM4B MUC1 OS9 PDZK1IP1 POU2AF1 SERP1 SLC25A11 SMIM24 SMIM3 SPP1 TMBIM4 TMEM147 TMEM179B VAPB	10 interacting genes: ANXA7 CAMK2G CCND2 LZTS1 NRBF2 RHOBTB1 RIOX2 RUNX1 SLC22A1 USP54
Entrez ID		6580	84159
HPRD ID		04007	18880
Ensembl ID		ENSG00000175003	ENSG00000150347
Uniprot IDs		O15245	Q14865
PDB IDs		8ET6 8ET7 8ET8 8JTS 8JTT 8JTV 8JTW 8JTX 8JTY 8JTZ 8JU0 8SC1 8SC2 8SC3 8SC4 8SC6	1IG6 2OEH
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Unfolded Protein Response Multivesicular Body, Internal Vesicle Response To Endoplasmic Reticulum Stress Muscle Organ Morphogenesis Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration
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