SLC6A9 and PPP2R3B

		SLC6A9	PPP2R3B
Description		solute carrier family 6 member 9	protein phosphatase 2 regulatory subunit B''beta
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GO Annotations	Cellular Component	Endosome Plasma Membrane Basal Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Synaptic Vesicle Membrane Dense Core Granule Asymmetric Synapse Presynaptic Membrane Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol Cilium
	Molecular Function	Amino Acid:sodium Symporter Activity Glycine Transmembrane Transporter Activity Symporter Activity Glycine:sodium Symporter Activity Transmembrane Transporter Activity	Calcium Ion Binding Protein Binding Protein Phosphatase Regulator Activity Metal Ion Binding
	Biological Process	Neurotransmitter Uptake Neurotransmitter Transport Amino Acid Transport Glycine Transport Sodium Ion Transmembrane Transport Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Synaptic Transmission, Glycinergic Glycine Secretion, Neurotransmission Positive Regulation Of Heme Biosynthetic Process Transport Across Blood-brain Barrier Glycine Import Across Plasma Membrane	Protein Dephosphorylation Regulation Of Cell Cycle
Pathways		SLC-mediated transport of neurotransmitters	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 29403010 32888494) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: GABRR1 NAPA PPP2R3B PRKCA STX1A TP53BP1	12 interacting genes: CDC6 DUSP12 HGS NAA10 NOD2 PPP2CA PPP2R1A PPP2R1B SHANK3 SLC6A9 TMEM14B UBC
Entrez ID		6536	28227
HPRD ID		03010	02276
Ensembl ID		ENSG00000196517	ENSG00000167393
Uniprot IDs		B7Z3A9 B7Z3W8 B7Z589 P48067	Q9Y5P8
PDB IDs		6ZBV 6ZPL 8WFI 8WFJ 8WFK 8WFL 9J8B 9J8C 9J8D	4I5L 4I5N 4MEW
Enriched GO Terms of Interacting Partners?		Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Synaptic Vesicle Priming Presynaptic Active Zone Membrane Protein-containing Complex Binding SNARE Binding Positive Regulation Of Exocytosis Myosin Head/neck Binding Glutamatergic Synapse Presynaptic Membrane Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Membrane Organization Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Membrane Fusion Regulation Of Insulin Secretion Protein Kinase C Signaling Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Histone H4K20me Methyltransferase Activity GABA Receptor Activity Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Exocytosis Histone H4K20me2 Reader Activity Desmosome Assembly ATP-dependent Protein Binding Response To Gravity Chloride Channel Inhibitor Activity Ubiquitin-modified Histone Reader Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Trans-synaptic Signaling GABA-A Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Synaptic Signaling GABA-A Receptor Complex Chemical Synaptic Transmission GABA-gated Chloride Ion Channel Activity Regulation Of Hormone Secretion Mitotic Nuclear Membrane Disassembly Diacylglycerol Binding Positive Regulation Of Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway	Protein Phosphatase Type 2A Complex Meiotic Sister Chromatid Cohesion, Centromeric Protein Serine/threonine Phosphatase Activity Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand INTAC Complex FAR/SIN/STRIPAK Complex Regulation Of Cell Cycle Process RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition T Cell Homeostasis Nuclear RNA Surveillance Homeostasis Of Number Of Cells Cytosol RNA Surveillance Protein Phosphatase Regulator Activity Sister Chromatid Cohesion Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Cycle RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity DNA-templated Transcription Elongation RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Meiotic Spindle Elongation Glycine Secretion, Neurotransmission Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Homeostasis Lateral Plasma Membrane Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Leukocyte Homeostasis Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Organelle Assembly Positive Regulation Of Heme Biosynthetic Process Regulation Of Synaptic Transmission, Glycinergic Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Detection Of Peptidoglycan Guanylate Kinase-associated Protein Clustering Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Protein Tyrosine Phosphatase Activity Spindle Assembly Regulation Of Heme Biosynthetic Process
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