BMP5 and CHRDL2

Number of citations of the paper that reports this interaction (PubMedID 14660436)
0

Data Source:
HPRD (in vivo)

		BMP5	CHRDL2
Description		bone morphogenetic protein 5	chordin like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity BMP Receptor Binding	Protein Binding BMP Binding
	Biological Process	Skeletal System Development Ossification Endocardial Cushion Formation Type B Pancreatic Cell Development Pericardium Morphogenesis Pattern Specification Process Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Tissue Development Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Steroid Biosynthetic Process Neural Fold Elevation Formation Cell Differentiation BMP Signaling Pathway Male Genitalia Development Hindbrain Development Negative Regulation Of Aldosterone Biosynthetic Process Regulation Of Cell Population Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Ear Development Positive Regulation Of Transcription By RNA Polymerase II Cell Development Cardiac Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Developmental Process Cartilage Development Pharyngeal System Development Positive Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Negative Regulation Of Mononuclear Cell Migration Anterior Head Development Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Allantois Development Negative Regulation Of Cortisol Biosynthetic Process	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway System Development Cartilage Development
Pathways
Drugs
Diseases
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 28869591 30598549) Lean body mass ( 28552196) Schizophrenia ( 34099189) Zinc levels ( 26025379)	Allergic rhinitis ( 25085501) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Microalbuminuria ( 26631737) Spine bone size ( 31053729)
Interacting Genes		5 interacting genes: BMPR1A CHRDL2 FST MEOX2 NOG	21 interacting genes: BANP BMP2 BMP4 BMP5 BMP6 BMP7 CHRD ENKD1 FAH FAM90A1 GDF5 GPSM3 HOXA1 INHBA MAPRE3 OTX1 PIK3R3 POU4F2 SLIT1 ZNF417 ZNF587
Entrez ID		653	25884
HPRD ID		00210	09881
Ensembl ID		ENSG00000112175	ENSG00000054938
Uniprot IDs		A8K694 M9VUD0 P22003	Q6WN34
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Neural Plate Pattern Specification BMP Signaling Pathway Pattern Specification Process Ventricular Compact Myocardium Morphogenesis Cartilage Development Regulation Of BMP Signaling Pathway Pharyngeal Arch Artery Morphogenesis Endocardial Cushion Formation Somite Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Heart Trabecula Morphogenesis Epithelial Cell Proliferation BMP Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Animal Organ Formation Cellular Response To BMP Stimulus Pituitary Gland Development Endoderm Development Cellular Response To Growth Factor Stimulus Ventricular Septum Morphogenesis Regulation Of Cardiac Muscle Cell Proliferation System Development Response To Growth Factor Negative Regulation Of Cell Migration Ventricular Cardiac Muscle Tissue Morphogenesis Mesoderm Formation Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Limb Development Embryonic Digit Morphogenesis Mesoderm Development Cardiac Muscle Tissue Morphogenesis Formation Of Primary Germ Layer Outflow Tract Morphogenesis Artery Morphogenesis Dorsal/ventral Pattern Formation Regulation Of Heart Growth Somatic Stem Cell Population Maintenance Negative Regulation Of BMP Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Muscle Tissue Morphogenesis Roof Of Mouth Development Animal Organ Development Regulation Of Animal Organ Morphogenesis Regulation Of Neural Crest Cell Differentiation	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction BMP Receptor Binding BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Activator Complex Cartilage Development Cytokine Activity Ossification Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Differentiation Ameloblast Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Positive Regulation Of Neuron Differentiation Skeletal System Development Regulation Of Aldosterone Biosynthetic Process Regulation Of Neuron Differentiation Positive Regulation Of Bone Mineralization Endocardial Cushion Formation Type B Pancreatic Cell Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Differentiation Positive Regulation Of Ossification Heart Development Negative Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Epithelial Cell Differentiation Protein Serine/threonine Kinase Activator Activity Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation Regulation Of Locomotion Regulation Of Ketone Biosynthetic Process Regulation Of Bone Mineralization Regulation Of Hormone Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neural Fold Elevation Formation Positive Regulation Of Cell Differentiation Regulation Of Animal Organ Formation Odontogenesis Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Aldosterone Biosynthetic Process
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