JMJD4 and SPAG8

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		JMJD4	SPAG8
Description		jumonji domain containing 4	sperm associated antigen 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Acrosomal Vesicle Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Spindle Cytosol Cytoskeleton Axonemal Microtubule Cilium Membrane Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Protein Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 4-dioxygenase Activity Catalytic Activity, Acting On A Protein	Protein Binding Microtubule Binding
	Biological Process	Regulation Of Gene Expression Protein Hydroxylation Positive Regulation Of Translational Termination	Spermatogenesis Single Fertilization Cell Differentiation Flagellated Sperm Motility Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Protein hydroxylation
Drugs
Diseases
GWAS		Height ( 20881960) Waist circumference adjusted for body mass index ( 34021172)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: ERBB2 SPAG8	88 interacting genes: ACTMAP ARMC5 B9D2 BATF2 CARM1 CCDC120 CCNC CDC23 CFP CSTF2 CSTF2T CTAG1A CTAG1B DMRT3 DOK3 DTX2 DYNLL2 EGFL7 FAM168B GIGYF1 GLYCTK GPSM3 HR INCA1 INTS11 JMJD4 KDM3B KLHL32 KRT34 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP26-1 KRTAP3-1 KRTAP6-2 KRTAP7-1 LASP1 MEOX1 METTL15 MGAT5B NEDD4L NHLRC4 NSD3 NUDT21 PATZ1 PEF1 PFDN5 PHF1 PITX1 PLA2G10 PRMT1 PRMT2 PRMT5 PRR35 RAN RBP3 RIPK4 RNF125 RUSC1 SERGEF SIGMAR1 SMUG1 SMYD1 SNRPB SNRPC SYNGAP1 TEKT3 TEKT5 TENT5B TRIB3 TRIM42 TSC1 TTC23 UBAP2 UBQLN1 UBQLN4 USP2 VPS37C YPEL3 ZBTB32 ZIC1 ZNF34 ZNF581
Entrez ID		65094	26206
HPRD ID		07774	12039
Ensembl ID		ENSG00000081692	ENSG00000137098
Uniprot IDs		Q9H9V9	A0A140VJV0 Q99932
PDB IDs			7UNG 8J07
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Negative Regulation Of Immature T Cell Proliferation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB4 Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Immature T Cell Proliferation In Thymus Semaphorin Receptor Complex Protein Localization To Postsynapse Regulation Of Protein Targeting To Membrane Motor Neuron Axon Guidance Protein Localization To Postsynaptic Membrane Positive Regulation Of Rho Protein Signal Transduction Peripheral Nervous System Development Schwann Cell Development Positive Regulation Of Transcription By RNA Polymerase I Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of T Cell Differentiation In Thymus ERBB2 Signaling Pathway Positive Regulation Of Protein Targeting To Membrane Cytoplasmic Vesicle Myelin Sheath Axonemal Microtubule Axonemal A Tubule Inner Sheath Positive Regulation Of MAP Kinase Activity Neuromuscular Junction Development Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Oligodendrocyte Differentiation Peptidyl-tyrosine Phosphorylation Cell Projection Regulation Of Transcription By RNA Polymerase I Response To Epidermal Growth Factor Semaphorin-plexin Signaling Pathway Receptor Localization To Synapse Negative Regulation Of T Cell Differentiation Male Germ Cell Nucleus Protein Localization To Synapse Positive Regulation Of Protein Serine/threonine Kinase Activity Coreceptor Activity Regulation Of MAP Kinase Activity Negative Regulation Of Lymphocyte Differentiation Basal Plasma Membrane	Intermediate Filament Protein-arginine N-methyltransferase Activity Protein Binding Histone Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Methylation Methyltransferase Activity Methylosome Protein Methylation Histone Arginine N-methyltransferase Activity MRNA Cleavage And Polyadenylation Specificity Factor Complex Keratin Filament Histone H3K9me/H3K9me2 Demethylase Activity Histone H3 Methyltransferase Activity Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Macromolecule Methylation
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