DDX31 and PRRC2B

		DDX31	PRRC2B
Description		DEAD-box helicase 31	proline rich coiled-coil 2B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Golgi Apparatus
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity	RNA Binding Protein Binding
	Biological Process	Ribosome Biogenesis	Cell Differentiation
Pathways
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Lung function ( 31902109) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: PRRC2B RNF10	48 interacting genes: AK8 ALG13 ANKHD1 APP ATN1 ATXN1 ATXN1L BAG4 BCAS2 CFAP77 CRK CTBP1 DAPK1 DDX11 DDX31 DIMT1 DMRTB1 DNAJC5 DPY30 EHMT2 ESS2 EXOSC1 EXOSC4 EXOSC7 FBXO7 GTF3C4 IPO5 LSM5 MRPL44 NIP7 NXF1 NXF5 PLPP7 PRPF39 QKI RBFOX2 RBPMS RERE RPL13 SETX SF1 SRPK2 SRSF4 TRNAU1AP TXNL4A UCK1 YTHDF1 YTHDF3
Entrez ID		64794	84726
HPRD ID		10860	13805
Ensembl ID		ENSG00000125485	ENSG00000288701
Uniprot IDs		A0AAK2PNZ4 Q9H8H2	Q5JSZ5 Q9BU62
PDB IDs
Enriched GO Terms of Interacting Partners?		Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Postsynaptic Signal Transduction Protein Monoubiquitination	RNA Binding Nucleus RNA Processing RNA Metabolic Process Nucleic Acid Binding RNA Splicing MRNA Metabolic Process Nucleolus MRNA Processing MRNA Binding Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleolar Exosome (RNase Complex) Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Macromolecule Metabolic Process Regulation Of RNA Splicing Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing POZ Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress Granule Assembly Negative Regulation Of Macromolecule Metabolic Process MRNA Splice Site Recognition Exoribonuclease Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Spliceosomal Complex Nuclear RNA Export Factor Complex U4 SnRNA 3'-end Processing Protein-RNA Complex Assembly Cytoplasm Transcription Corepressor Activity Negative Regulation Of Metabolic Process Spliceosomal Complex Assembly Memory Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nuclear MRNA Surveillance Nuclear Inclusion Body N6-methyladenosine-containing RNA Reader Activity
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