FNDC3B and TXN

Number of citations of the paper that reports this interaction (PubMedID 36811957)
49

Data Source:
BioGRID (unspecified method)

		FNDC3B	TXN
Description		fibronectin type III domain containing 3B	thioredoxin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	RNA Binding Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Protein-disulfide Reductase Activity Protein Homodimerization Activity Protein-disulfide Reductase [NAD(P)H] Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Response To Radiation Cellular Homeostasis Positive Regulation Of DNA Binding Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Detoxification Of Hydrogen Peroxide Response To Nitric Oxide
Pathways			Oxidative Stress Induced Senescence Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes Protein repair The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Appendicular lean mass ( 33097823) Bell's palsy ( 33602968) Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal hysteresis ( 30894546) Corneal resistance factor ( 30894546 31246245) Corneal structure ( 23291589) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 33627673) Glycated hemoglobin levels ( 34059833 28898252) Heart rate ( 23583979) Height ( 31562340 33713608 23563607 28552196 25282103 25429064) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 25173106 31798171 28073927 29785010 30054594 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Keratoconus ( 33649486) Mean corpuscular hemoglobin ( 32888494) Myocardial infarction ( 33532862) Parkinson's disease ( 26227905) PR interval ( 32439900) Pulse pressure ( 30224653) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triptolide cytotoxicity ( 26121980) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		124 interacting genes: ABHD11 ABHD8 ACTG1 ACTMAP ADGRF5 AHNAK ALB ANXA2 ATP1A1 ATP5F1A BBS2 BICRAL BRWD1 C10orf55 C22orf15 CAMK2D CAP1 CAPN3 CDC42 CEMP1 CFL1 DAPL1 DSTN DUSP10 EEF1E1 EGFR EIF5A2 ENO1 ERCC6 ERH ERI3 FUS GAS2L3 GOLT1B GTF2F1 HAPLN2 HNRNPD HNRNPK HSP90AB4P HSPA1A HSPA5 HSPA7 HSPA8 HSPB1 HSPD1 HSPH1 KARS1 KLHDC7B KRTAP11-1 L3MBTL3 LARP4 MBD3L1 MBOAT7 MCCD1 MVP MYH14 MYL6 NAGK NCAM2 NCK1 NDUFAB1 P4HB PARP1 PC PGK1 PIK3R4 PKLR POGZ POU6F2 PPP6R2 PRKAA2 PSMA3 PTMA RAB1A RAB1B RAN REL RPL12 RPL15 RPL17 RPL23 RPL28 RPL34 RPS14 RPS3 RPS3A RPS6 RUSC1 SNRPD3 SOD1 SPCS2 SPMIP10 SPMIP5 SPSB2 SRARP STPG4 SUGT1 SUOX SYNCRIP TEKT5 TEPSIN TESMIN TEX48 TGM2 TIAM1 TKT TOX4 TPM3 TRAF2 TRIM16 TRIM35 TRIM42 TRIP13 TTN TUBB4A TUBGCP6 TXN UBA52 UBAP2 USP54 VAC14 YPEL3 YWHAZ ZMYND19	43 interacting genes: ACTN1 ACTN4 ANKRD11 APEX1 C1QA C4BPA CDKN1A CEBPA CFP COL1A1 COPS5 DDIT4L DNAJA1 DYNLT1 EGFR ERBB2 ERBB3 ERBB4 FNDC3B FST GFER GPRASP2 MAP3K5 MLH1 MRFAP1 MYD88 NCF4 NFE2 NFKB1 NIF3L1 NR3C1 NUP62 PTEN SERTAD3 SIAH1 SPG21 SRPK2 TEX13A TP53 TRAF2 TXNIP UCHL5 VIM
Entrez ID		64778	7295
HPRD ID		10943	01761
Ensembl ID		ENSG00000075420	ENSG00000136810
Uniprot IDs		Q53EP0	H9ZYJ2 P10599
PDB IDs			1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4LL1 4LL4 4OO4 4OO5 4POK 4POL 4POM 4PUF 4TRX 5DQY
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cytosol Cytoplasm Cytoplasmic Translation Cytosolic Ribosome Focal Adhesion Ribonucleoprotein Complex RNA Binding ATP-dependent Protein Folding Chaperone Translation Structural Constituent Of Ribosome Ribosome Protein Refolding Cadherin Binding Cytosolic Large Ribosomal Subunit Protein-containing Complex Melanosome Protein Binding Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding ATP Metabolic Process Protein Metabolic Process Protein Phosphatase Binding Cytosolic Small Ribosomal Subunit Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Nucleotide Binding Response To Nitric Oxide Protein Folding Positive Regulation Of Protein Metabolic Process Organophosphate Metabolic Process Enzyme Binding Actin Filament-based Process Macromolecule Metabolic Process Nucleotide Metabolic Process Nucleus Vesicle Structural Molecule Activity Conferring Elasticity Purine Nucleotide Metabolic Process Protein Folding Chaperone Nucleobase-containing Small Molecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway ATP Binding Positive Regulation Of Gene Expression Nicotinamide Nucleotide Metabolic Process Unfolded Protein Binding Nucleoside Phosphate Metabolic Process Cellular Response To Nitric Oxide	Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Response To Epidermal Growth Factor Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Developmental Process Regulation Of Gene Expression ERBB2 Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Response To Stress ERBB Signaling Pathway Cytoplasm Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Cell Differentiation Cellular Response To Epidermal Growth Factor Stimulus ERBB3:ERBB2 Complex Positive Regulation Of Programmed Cell Death Glial Cell Differentiation Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signaling Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Cellular Senescence Programmed Necrotic Cell Death Positive Regulation Of MiRNA Metabolic Process
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