CCDC14 and CSNK1E

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		CCDC14	CSNK1E
Description		coiled-coil domain containing 14	casein kinase 1 epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cilium Microtubule Cytoskeleton Centriolar Satellite Ciliary Basal Body	Nucleus Nucleoplasm Cytoplasm Cytosol Growth Cone Neuronal Cell Body Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Substantia Nigra Development Protein Localization To Centrosome	DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Intracellular Protein Localization Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Circadian Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Circadian Behavior Negative Regulation Of Small GTPase Mediated Signal Transduction Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways			WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A AURKA Activation by TPX2 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			Seliciclib Umbralisib
Diseases
GWAS		Intelligence (MTAG) ( 29326435)	Keratoconus ( 31855235) Mastocytosis ( 32752121)
Interacting Genes		17 interacting genes: APP CALM1 CEP63 CSNK1D CSNK1E DDX6 KDM1A MAGEA11 MAGEB4 MAPK14 PEX5 PIK3R3 PLAC9 PNKP RNF8 TXLNB UBQLN4	62 interacting genes: AKAP17A AKAP9 ANKRD6 APC APP ARHGEF1 AXIN1 AXIN2 BBS10 BHLHE41 BID BMAL1 CADM4 CCDC14 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HAUS7 HES1 KAT7 NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRC PTPRD RAD17 RAD54B RBX1 RORA RORC SNCA SOCS3 TAFAZZIN TAOK1 TLE5 TNS2 TRIM2 TRIM3 WDCP YAP1 ZMYND8 ZNF227 ZNF618
Entrez ID		64770	1454
HPRD ID		07801	02919
Ensembl ID		ENSG00000175455	ENSG00000213923
Uniprot IDs		J3QT39 Q49A88	P49674 Q5U045
PDB IDs			4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Regulation Of Double-strand Break Repair Regulation Of Canonical Wnt Signaling Pathway Response To Radiation DNA Damage Response Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Repair Regulation Of Cellular Response To Stress Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Neuron Maturation Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Spindle Pole Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of DNA Recombination DNA Repair-dependent Chromatin Remodeling Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Metabolic Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Protein Metabolic Process Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Cytosol Cellular Response To Nerve Growth Factor Stimulus Spindle Microtubule Regulation Of Proteasomal Protein Catabolic Process Concave Side Of Sperm Head Positive Regulation Of Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of DNA Metabolic Process Cellular Response To CAMP	Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Signal Transduction Rhythmic Process Photoperiodism Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Radiation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Circadian Rhythm Regulation Of Canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process E-box Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Signal Transduction Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription
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