SLC71A1 and DPH5

		SLC71A1	DPH5
Description		solute carrier family 71 member 1	diphthamide biosynthesis 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Cytosol
	Molecular Function	Transmembrane Transporter Activity	Methyltransferase Activity Transferase Activity Diphthine Methyl Ester Synthase Activity
	Biological Process	Acrosome Assembly Spermatogenesis Spermatid Development Spermatid Nucleus Differentiation Sperm Mitochondrion Organization Transmembrane Transport	Protein Histidyl Modification To Diphthamide Methylation
Pathways			Synthesis of diphthamide-EEF2
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS			Irritable bowel syndrome ( 29673008) QT interval (drug interaction) ( 23459443)
Interacting Genes		2 interacting genes: DPH5 HTR2C	3 interacting genes: RUSC1 SLC30A7 SLC71A1
Entrez ID		64645	51611
HPRD ID		11022	13037
Ensembl ID		ENSG00000156875	ENSG00000117543
Uniprot IDs		Q96MC6	B3KWP1 Q9H2P9
PDB IDs
Enriched GO Terms of Interacting Partners?		Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding G Protein-coupled Serotonin Receptor Complex Regulation Of Corticotropin-releasing Hormone Secretion Diphthine Methyl Ester Synthase Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Protein Histidyl Modification To Diphthamide Serotonin Binding Serotonin Receptor Signaling Pathway Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Appetite CGMP-mediated Signaling Behavioral Fear Response Regulation Of Phospholipid Metabolic Process Behavioral Defense Response Fear Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Fat Cell Differentiation Multicellular Organismal Response To Stress Feeding Behavior Calcium Ion Transmembrane Import Into Cytosol Regulation Of Calcium-mediated Signaling	Sperm Mitochondrion Organization Golgi Cis Cisterna Membrane Zinc Ion Import Into Golgi Lumen Spermatid Nucleus Differentiation Zinc Ion Import Into Organelle Monoatomic Cation Transmembrane Transporter Activity Acrosome Assembly Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Intracellular Zinc Ion Homeostasis Cytoplasmic Vesicle Sarcoplasmic Reticulum Membrane
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