EBF2 and EBF3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		EBF2	EBF3
Description		EBF transcription factor 2	EBF transcription factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell Fate Determination Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Adipose Tissue Development Positive Regulation Of Cold-induced Thermogenesis	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways		Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Dupuytren's disease ( 28886342) Hip index ( 34021172) Inguinal hernia ( 26686553) Major depressive disorder ( 27479909) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple system atrophy ( 27629089) Prostate cancer ( 23535732) Systolic blood pressure ( 27841878 28739976) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Erectile dysfunction ( 30583798) Metabolite levels ( 23823483) Sleep time ( 23728906)
Interacting Genes		3 interacting genes: EBF3 TRAF1 TRAF2	2 interacting genes: ATPAF2 EBF2
Entrez ID		64641	253738
HPRD ID		16848	16818
Ensembl ID		ENSG00000221818	ENSG00000108001
Uniprot IDs		B2RNT0 B7Z934 Q9HAK2	H0Y3W9 Q9H4W6
PDB IDs			3MUJ 3N50
Enriched GO Terms of Interacting Partners?		Thioesterase Binding Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity TORC2 Complex Disassembly Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Ubiquitin Protein Ligase Binding CD27 Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Zinc Ion Binding CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Cellular Response To Reactive Nitrogen Species Response To Nitric Oxide Programmed Necrotic Cell Death Positive Regulation Of T Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of MAP Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-2 Production Vesicle Membrane Signal Transduction Involved In Regulation Of Gene Expression Regulation Of T Cell Cytokine Production Regulation Of RNA Metabolic Process Apoptotic Process Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process	Mitochondrial Proton-transporting ATP Synthase Complex Assembly Proton-transporting ATP Synthase Complex Assembly
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