SUDS3 and SRPK1

Number of citations of the paper that reports this interaction (PubMedID 23602568)
0

Data Source:
BioGRID (enzymatic study)

		SUDS3	SRPK1
Description		SIN3A corepressor complex component SDS3	SRSF protein kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Sin3-type Complex	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix Nuclear Speck
	Molecular Function	Histone Deacetylase Activity Protein Binding Enzyme Binding Histone Deacetylase Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Apoptotic Process Regulation Of Gene Expression Substantia Nigra Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance	Spliceosomal Complex Assembly MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Cell Differentiation Sperm DNA Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing
Pathways		HDACs deacetylate histones NoRC negatively regulates rRNA expression Ub-specific processing proteases Potential therapeutics for SARS	Maturation of nucleoprotein Replacement of protamines by nucleosomes in the male pronucleus
Drugs
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal sclerosis ( 25188341) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		9 interacting genes: BRMS1 COL6A3 CSNK2A1 DYNLL1 GOLGA2 HDAC1 LDOC1 PTEN SRPK1	169 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARK2N ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CIMAP1D CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PPIL3 PRM1 PRPF38A PTK2 PTPN2 RBM23 RBMS2 RIMS4 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SANBR SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRRM1 SRSF1 SRSF10 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP7 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2
Entrez ID		64426	6732
HPRD ID		12196	15992
Ensembl ID		ENSG00000111707	ENSG00000096063
Uniprot IDs		Q9H7L9	Q96SB4
PDB IDs			1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD 7DD1 7PQS 7ZKS
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Cell Death Programmed Cell Death Apoptotic Process Meiotic Spindle Organization Meiotic Spindle Assembly Negative Regulation Of Stem Cell Population Maintenance NF-kappaB Binding Rhythmic Process Membraneless Organelle Assembly Organelle Assembly Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Motility Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Metabolic Process Spindle Assembly Enzyme Binding Krueppel-associated Box Domain Binding Negative Regulation Of Locomotion Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Collagen Type VI Trimer Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body PML Body Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Lysine Delactylase Activity Fungiform Papilla Formation Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Positive Regulation Of Protein Deacetylation Negative Regulation Of Phosphorylation Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Glycosylation Histone Deacetylase Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Circadian Rhythm Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Mitotic Spindle	RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nucleoplasm Nucleus MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleic Acid Binding Protein Kinase Activity Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Kinase Activity Negative Regulation Of RNA Splicing Spliceosomal Complex Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Protein-RNA Complex Assembly Pre-mRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Alternative MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific MRNA Binding Main Axon Response To Starvation Regulation Of Toll Signaling Pathway Catalytic Step 2 Spliceosome Protein Autophosphorylation IkappaB Kinase Complex Positive Regulation Of Viral Process Protein Phosphorylation Positive Regulation Of RNA Splicing
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