INF2 and UBE2R2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		INF2	UBE2R2
Description		inverted formin 2	ubiquitin conjugating enzyme E2 R2
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GO Annotations	Cellular Component	Cytoplasm Actin Filament Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Mitochondrial Fission	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS			Bipolar disorder ( 20351715) Body mass index ( 25673413) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: BDKRB2 COA8 CSNK2A1 UBE2R2	26 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 DTX3L DZIP3 FBXW5 GSC2 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 SDCBP UBA1 UBC
Entrez ID		64423	54926
HPRD ID		08648	15602
Ensembl ID		ENSG00000203485	ENSG00000107341
Uniprot IDs		Q27J81	Q712K3
PDB IDs		8RV2 9AZ4 9AZP 9AZQ 9B03 9B0K 9FJN 9FJW	6NYO 8PQL 8Q7R 8R5H
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Bradykinin Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Type 1 Angiotensin Receptor Binding Protein Stabilization Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Matrix Side Of Mitochondrial Inner Membrane Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Response To Osmotic Stress Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Protein Stability Regulation Of Response To Osmotic Stress MRNA Methylguanosine-cap Decapping Intracellular Signal Transduction Arachidonate Secretion Response To Salt Stress RNA Decapping Mitochondrial Cytochrome C Oxidase Assembly Regulation Of Cellular Response To Stress Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Sin3-type Complex Respiratory Chain Complex IV Assembly Execution Phase Of Apoptosis Protein Localization To Site Of Double-strand Break PcG Protein Complex Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Positive Regulation Of Catabolic Process Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Ubiquitin Protein Ligase Binding Transferase Activity Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Targeting To Mitochondrion Regulation Of Mitophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization SCF Ubiquitin Ligase Complex Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Autoubiquitination Regulation Of Programmed Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction
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