SGCA and FSTL1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
50

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		SGCA	FSTL1
Description		sarcoglycan alpha	follistatin like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Cell-cell Junction Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma Membrane Raft	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding	Calcium Ion Binding Protein Binding Heparin Binding
	Biological Process	Muscle Contraction Muscle Organ Development	Cell Differentiation Regulation Of BMP Signaling Pathway Negative Regulation Of Apoptotic Process Endothelial Cell Migration Endothelial Cell Differentiation Hematopoietic Stem Cell Homeostasis
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Signaling by BMP Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Temporomandibular joint disorder ( 28081371) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 30072576) Obesity-related traits ( 23251661)
Interacting Genes		10 interacting genes: FN1 FSTL1 HDAC5 ITGB1BP2 SGCB SGCD SGTA SGTB TAF1 TUBG1	6 interacting genes: APPBP2 CRK MTNR1A MTNR1B SGCA SGTA
Entrez ID		6442	11167
HPRD ID		02525	16120
Ensembl ID		ENSG00000108823	ENSG00000163430
Uniprot IDs		A0A0S2Z4P8 A0A0S2Z4Q1 Q16586	Q12841
PDB IDs
Enriched GO Terms of Interacting Partners?		TRC Complex Sarcoglycan Complex Dystroglycan Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Muscle Organ Development Dystrophin-associated Glycoprotein Complex Muscle Structure Development Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cardiac Muscle Cell Development Cardiac Cell Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Signaling Pathway Protein Targeting To Membrane Striated Muscle Cell Development Response To Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endothelial Cell Migration Negative Regulation Of Protein Autoubiquitination Microtubule Nucleator Activity Muscle Cell Development Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Identical Protein Binding Sarcolemma Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Calcium-independent Cell-matrix Adhesion BAT3 Complex Binding Acetyl-CoA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase I General Transcription Initiation Factor Activity Histone H4K16ac Reader Activity Polar Microtubule Negative Regulation Of Proteolysis	Melatonin Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
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