IKZF4 and IKZF5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		IKZF4	IKZF5
Description		IKAROS family zinc finger 4	IKAROS family zinc finger 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Protein-containing Complex	Nucleus Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Alopecia areata ( 20596022 25608926) Anorexia nervosa ( 28494655) Asthma ( 32700739 31959851 31619474 21804548) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune traits (pleiotropy) ( 30572963) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cognitive function ( 25644384) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil percentage of granulocytes ( 27863252) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Type 1 diabetes ( 21829393 25751624 18198356) Vitiligo ( 27723757 22561518)
Interacting Genes		20 interacting genes: CDC7 CHD4 CSNK1D FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 MCRS1 MOB1A MOB3C NFKBIA NRG1 SIN3A SIN3B TCAF1 TCEA2 TXK	9 interacting genes: CCDC85B IKZF1 IKZF2 IKZF3 IKZF4 LDOC1 NUDT22 PIAS1 UBE2I
Entrez ID		64375	64376
HPRD ID		05874	05873
Ensembl ID		ENSG00000123411	ENSG00000095574
Uniprot IDs		F8VPL6 Q9H2S9	Q9H5V7
PDB IDs		2MA7
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Sin3-type Complex Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II NF-kappaB Binding Histone Deacetylase Binding Cellular Response To Dopamine Negative Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Zinc Ion Binding NuRD Complex DNA Recombination Protein-containing Complex Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Catecholamine Stimulus Positive Regulation Of Macromolecule Metabolic Process Response To Catecholamine Chromatin Organization Regulation Of Cell Fate Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle G2/M Phase Transition Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Locomotion	Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Presynaptic Cytosol Postsynaptic Cytosol SUMO Transferase Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Protein Domain Specific Binding DNA-binding Transcription Factor Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Protein Sumoylation Mesoderm Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II SUMO Conjugating Enzyme Activity GDP-mannose Hydrolase Activity Nucleoplasm RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding UDP-sugar Diphosphatase Activity PML Body RING-like Zinc Finger Domain Binding Zinc Ion Binding SUMO Ligase Complex HLH Domain Binding Nucleus DNA Binding Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Small Protein Activating Enzyme Binding Maternal Process Involved In Parturition Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Metal Ion Binding Delta-catenin Binding Mitotic Nuclear Membrane Reassembly Maternal Placenta Development Cellular Response To Muramyl Dipeptide Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transferase Complex SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Lymphocyte Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process
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