ABCG5 and ABCG8

Number of citations of the paper that reports this interaction (PubMedID 12208867)
49

Data Source:
HPRD (in vivo)

		ABCG5	ABCG8
Description		ATP binding cassette subfamily G member 5	ATP binding cassette subfamily G member 8
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex Apical Part Of Cell	Plasma Membrane Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Cholesterol Transfer Activity ABC-type Transporter Activity	Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Cholesterol Transfer Activity ABC-type Transporter Activity
	Biological Process	Lipid Transport Response To Nutrient Response To Xenobiotic Stimulus Response To Ionizing Radiation Negative Regulation Of Intestinal Phytosterol Absorption Response To Muscle Activity Sterol Transport Intestinal Cholesterol Absorption Response To Nutrient Levels Cholesterol Efflux Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport Triglyceride Homeostasis	Lipid Transport Response To Nutrient Response To Xenobiotic Stimulus Negative Regulation Of Intestinal Phytosterol Absorption Response To Muscle Activity Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Response To Nutrient Levels Cholesterol Efflux Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport Sterol Homeostasis Triglyceride Homeostasis
Pathways		ABC transporters in lipid homeostasis Defective ABCG8 causes GBD4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	ABC transporters in lipid homeostasis Defective ABCG8 causes GBD4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases		Sitosterolemia	Sitosterolemia
GWAS		C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 20686565 24097068) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) LDL cholesterol ( 19060911 20686565 24097068) Lipid metabolism phenotypes ( 19936222)	Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 25961943 28270201 24097068 20686565) Coronary artery disease ( 33020668 29212778 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gallstone disease ( 27094239 30504769 30692554 30325047 17632509) LDL cholesterol ( 19060906 20686565 23726366 25961943 30275531) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817 32154731) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Phytosterol levels ( 20529992) Refractive error ( 32231278) Total cholesterol levels ( 30275531 33339817)
Interacting Genes		1 interacting genes: ABCG8	9 interacting genes: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 MESD NR4A1 NUPR1
Entrez ID		64240	64241
HPRD ID		05678	05679
Ensembl ID		ENSG00000138075	ENSG00000143921
Uniprot IDs		Q9H222	Q9H221
PDB IDs		5DO7 7JR7 7R87 7R88 7R89 7R8A 7R8B 8CUB	5DO7 7JR7 7R87 7R88 7R89 7R8A 7R8B 8CUB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Absorption ATP-binding Cassette (ABC) Transporter Complex Regulation Of Intestinal Cholesterol Absorption Intestinal Cholesterol Absorption Regulation Of Intestinal Lipid Absorption Intestinal Lipid Absorption Regulation Of Intestinal Absorption Cholesterol Efflux Cholesterol Transfer Activity ATPase-coupled Transmembrane Transporter Activity Intestinal Absorption Response To Muscle Activity Acylglycerol Homeostasis Triglyceride Homeostasis ABC-type Transporter Activity Cholesterol Transport Response To Activity Sterol Transport Digestive System Process Phospholipid Transport Sterol Homeostasis Cholesterol Homeostasis Organophosphate Ester Transport Response To Nutrient Organic Hydroxy Compound Transport Lipid Homeostasis Protein Dimerization Activity Receptor Complex Response To Xenobiotic Stimulus Lipid Transport Protein Heterodimerization Activity ATP Hydrolysis Activity Apical Plasma Membrane Response To Nutrient Levels	Regulation Of Type B Pancreatic Cell Proliferation
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