P3H1 and MIRLET7I

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		P3H1	MIRLET7I
Description		prolyl 3-hydroxylase 1	microRNA let-7i
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Protein-containing Complex Extracellular Exosome	Extracellular Space Cytoplasm RISC Complex Extracellular Vesicle
	Molecular Function	Iron Ion Binding Protein Binding Collagen Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Procollagen-proline 3-dioxygenase Activity L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Protein Folding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Protein Hydroxylation Collagen Fibril Organization Regulation Of Ossification Negative Regulation Of Cell Growth Collagen Metabolic Process Regulation Of Protein Secretion Protein Stabilization Bone Development Negative Regulation Of Post-translational Protein Modification	Negative Regulation Of Gene Expression MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Defense Response To Protozoan
Pathways		Collagen biosynthesis and modifying enzymes
Drugs		Ascorbic acid Proline
Diseases		Osteogenesis imperfecta
GWAS
Interacting Genes		14 interacting genes: CDC42 JAK1 MIR1-2 MIR107 MIR141 MIR18B MIR19A MIR19B1 MIR9-3 MIR92A1 MIRLET7A2 MIRLET7B MIRLET7I SLC2A4	113 interacting genes: AGO2 AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC5L CELF1 CELF2 CHERP CPSF1 CRTAP CSTF1 CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EIF2AK2 ELAVL1 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 GRSF1 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 P3H1 PAXBP1 PDCD11 PLOD1 PLRG1 PTBP1 PUF60 PUM1 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM17 RBM4 RBM4B RBM5 RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR ZNF106 ZNF346
Entrez ID		64175	406891
HPRD ID		11227
Ensembl ID		ENSG00000117385	ENSG00000199179
Uniprot IDs		Q32P28
PDB IDs		8K0E 8K0F 8K0I 8K0M 8K17 8KC9
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Negative Regulation Of Extracellular Matrix Organization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Regulation Of Gene Expression Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Macromolecule Biosynthetic Process Regulation Of Sprouting Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Translation Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Extracellular Matrix Assembly Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Bacterial Lipopeptide Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration Regulation Of Macromolecule Metabolic Process Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death MRNA Destabilization Negative Regulation Of Defense Response Extracellular Space RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Regulation Of Vasculature Development	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of RNA Splicing Spliceosomal Complex Nucleoplasm Post-transcriptional Regulation Of Gene Expression Catalytic Step 2 Spliceosome MiRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process RNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MRNA Stabilization Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Protein-RNA Complex Assembly TRNA Aminoacylation Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process MiRNA Processing Nucleolus U2 SnRNP TRNA Metabolic Process Ligase Activity
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