LIN7B and KCNJ12

Number of citations of the paper that reports this interaction (PubMedID 15024025)
0

Data Source:
HPRD (in vivo)

		LIN7B	KCNJ12
Description		lin-7 cell polarity scaffold B	potassium inwardly rectifying channel subfamily J member 12
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Plasma Membrane Membrane T-tubule Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity	Inward Rectifier Potassium Channel Activity Protein Binding Metal Ion Binding
	Biological Process	Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Homotetramerization Potassium Ion Import Across Plasma Membrane
Pathways		Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Dofetilide Ranolazine Ritodrine Miconazole Yohimbine Dronedarone Butamben
Diseases
GWAS			Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Height ( 20881960 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip ratio ( 25673412)
Interacting Genes		20 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 DNAH1 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP7 NTAQ1 PSMB1 SNCA TCEANC TRAPPC12	18 interacting genes: ABLIM1 APBA1 CASK CAV3 DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		64130	3768
HPRD ID		10040	09083
Ensembl ID		ENSG00000104863	ENSG00000184185
Uniprot IDs		Q9HAP6	Q14500
PDB IDs		2DKR
Enriched GO Terms of Interacting Partners?		Modulation Of Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity PDZ Domain Binding Regulation Of Long-term Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Potential Regulation Of Nervous System Process Ligand-gated Ion Channel Signaling Pathway Cellular Component Assembly Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Protein-containing Complex Assembly Glutamate-gated Calcium Ion Channel Activity Excitatory Postsynaptic Potential Plasma Membrane Synapse Synaptic Membrane Scaffold Protein Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Monoatomic Ion Transport Regulation Of Protein-containing Complex Assembly Protein-containing Complex Organization Protein Localization To Cell Junction Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Protein Tetramerization Postsynaptic Density Schaffer Collateral - CA1 Synapse Regulation Of Postsynaptic Membrane Potential Neuron Projection Terminus Postsynaptic Density Membrane Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Inward Rectifier Potassium Channel Activity Regulation Of System Process Dendrite Cytoplasm Monoatomic Ion Transport Synaptic Vesicle Metal Ion Transport Regulation Of Presynaptic Membrane Potential Cell-cell Signaling Excitatory Synapse Ligand-gated Monoatomic Ion Channel Activity	Neuromuscular Junction Dystrophin-associated Glycoprotein Complex MPP7-DLG1-LIN7 Complex Postsynaptic Density Membrane Synapse L27 Domain Binding Sarcolemma Basolateral Plasma Membrane Muscle System Process Intracellular Protein Localization PDZ Domain Binding Ionotropic Glutamate Receptor Binding Synaptic Signaling Plasma Membrane Cell-cell Junction Muscle Contraction Regulation Of Sodium Ion Transmembrane Transport GMP Kinase Activity Anchoring Junction Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Communication Bicellular Tight Junction GDP Metabolic Process Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Nitric-oxide Synthase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse System Process Chemical Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Trans-synaptic Signaling Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction Cell-cell Signaling Regulation Of Heart Contraction Protein Localization To Cell Junction Actin Binding Signaling Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction GMP Metabolic Process Postsynaptic Membrane Kinase Binding Regulation Of Heart Rate Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Syntrophin Complex
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