CHP2 and SLC9A3

Number of citations of the paper that reports this interaction (PubMedID 8901634)
41

Data Source:
HPRD (in vitro, in vivo)

		CHP2	SLC9A3
Description		calcineurin like EF-hand protein 2	solute carrier family 9 member A3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane	Endosome Early Endosome Plasma Membrane Brush Border Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity PDZ Domain Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatase Activity Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Calcium Ion	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport
Pathways			Sodium/Proton exchangers
Drugs			Tenapanor
Diseases
GWAS		Daytime nap ( 33568662)	Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Estimated glomerular filtration rate ( 31152163) Lung disease severity in cystic fibrosis ( 26417704) Ulcerative colitis ( 23128233 28067908)
Interacting Genes		7 interacting genes: DCTN5 MDFI SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5	10 interacting genes: ADCY2 CHP1 CHP2 LRP2 MAST2 NEDD4L NHERF1 NHERF2 PDZK1 SHANK2
Entrez ID		63928	6550
HPRD ID		14259	01660
Ensembl ID		ENSG00000166869	ENSG00000066230
Uniprot IDs		O43745	P48764
PDB IDs		2BEC	7X2U
Enriched GO Terms of Interacting Partners?		Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Sodium Ion Import Across Plasma Membrane Regulation Of Cellular PH Regulation Of Intracellular PH Antiporter Activity Inorganic Cation Import Across Plasma Membrane Regulation Of PH Sodium Ion Transmembrane Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Chemical Homeostasis Apical Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Homeostatic Process Recycling Endosome Membrane Regulation Of The Force Of Heart Contraction By Cardiac Conduction Cation-transporting ATPase Complex Regulation Of Biological Quality Transporter Complex Transepithelial Ammonium Transport Positive Regulation Of The Force Of Heart Contraction Glandular Epithelial Cell Development Regulation Of Cardiac Muscle Cell Membrane Potential Protein Phosphatase 2B Binding Neuron Spine Dynactin Complex Gastric Acid Secretion Cardiac Muscle Cell Contraction Positive Regulation Of Action Potential Arrestin Family Protein Binding Cellular Response To Antibiotic Basolateral Plasma Membrane	Brush Border Membrane Apical Plasma Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 3 Metabotropic Glutamate Receptor Binding Plasma Membrane Phosphatase Binding Regulation Of Sodium Ion Transport Regulation Of Phosphatase Activity Negative Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Import Across Plasma Membrane Regulation Of Dephosphorylation Positive Regulation Of Protein Targeting To Membrane Microvillus Membrane Sodium Ion Transport Protein Localization To Plasma Membrane Regulation Of Protein Targeting To Membrane Intracellular Protein Localization Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Sodium Ion Transmembrane Transport Transmembrane Transport Metal Ion Transport Protein Localization To Cell Periphery Extracellular Exosome Endomembrane System Brush Border Regulation Of Protein Import Into Nucleus Renal Phosphate Ion Absorption Monoatomic Cation Transport Protein Localization To Membrane Positive Regulation Of Establishment Of Protein Localization Regulation Of Metal Ion Transport Transport Across Blood-brain Barrier PDZ Domain Binding Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Apical Part Of Cell Regulation Of Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Monoatomic Ion Transport Regulation Of Protein Localization Signaling Receptor Binding Regulation Of Calcium-mediated Signaling Negative Regulation Of Monoatomic Ion Transport Beta-catenin Binding Membrane Folate Transmembrane Transport
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