CCL4 and CCR8

Number of citations of the paper that reports this interaction (PubMedID 9521068)
0

Data Source:
HPRD (in vitro, in vivo)

		CCL4	CCR8
Description		C-C motif chemokine ligand 4	C-C motif chemokine receptor 8
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Cell Migration Host-mediated Suppression Of Viral Transcription Eosinophil Chemotaxis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Chemotaxis	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		28 interacting genes: ACKR2 ARL13B CCL3 CCR1 CCR3 CCR5 CCR8 CNR2 CXCL8 GJA8 GPR152 GPRC5D HRAS MARCHF2 MRM1 PRRG2 SLC10A6 SLC18A1 SLC30A2 SLC30A8 SLC7A1 TAS2R5 TIMMDC1 TMEM14B TMEM179B TMEM31 TMEM86B UNC93A	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		6351	1237
HPRD ID		01657	03497
Ensembl ID		ENSG00000275302	ENSG00000179934
Uniprot IDs		P13236	P51685
PDB IDs		1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL	8KFX 8KFY 8KFZ 8TLM 8U1U 8XML
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cell Chemotaxis Chemotaxis Chemokine-mediated Signaling Pathway Locomotion G Protein-coupled Receptor Activity Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway Membrane Plasma Membrane Chemokine (C-C Motif) Ligand 5 Binding Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Migration Immune Response Inflammatory Response Response To Cytokine Response To Peptide Zinc:proton Antiporter Activity Cell Motility Leukocyte Migration Cytokine-mediated Signaling Pathway Intracellular Signaling Cassette Cellular Response To Cytokine Stimulus Transport Vesicle Membrane Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Zinc Ion Import Into Organelle Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Monoatomic Cation Transport Defense Response External Side Of Plasma Membrane Sarcoplasmic Reticulum Calcium Ion Transport Dendritic Cell Chemotaxis Metal Ion Transport Transmembrane Transport Response To Interleukin-1 Monoatomic Cation Transmembrane Transporter Activity Import Into Cell Negative Regulation Of Bone Mineralization Positive Regulation Of Leukocyte Chemotaxis Immune System Process Monoatomic Ion Transport Positive Regulation Of Neuroinflammatory Response Secretory Granule Membrane Monocyte Chemotaxis Zinc Ion Transmembrane Transporter Activity Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity	Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex
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