S100A9 and USP13

		S100A9	USP13
Description		S100 calcium binding protein A9	ubiquitin specific peptidase 13
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Extracellular Exosome Calprotectin Complex S100A9 Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Antioxidant Activity Toll-like Receptor 4 Binding Metal Ion Binding Calcium-dependent Protein Binding Arachidonate Binding RAGE Receptor Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Protein-folding Chaperone Binding Proteasome Binding BAT3 Complex Binding K48-linked Deubiquitinase Activity
	Biological Process	Immune System Process Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Autophagy Apoptotic Process Chemotaxis Inflammatory Response Cell-cell Signaling Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Cell Growth Neutrophil Chemotaxis Regulation Of Toll-like Receptor Signaling Pathway Autocrine Signaling Peptidyl-cysteine S-trans-nitrosylation Defense Response To Bacterium Endothelial Cell Migration Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Regulation Of Cytoskeleton Organization Regulation Of Respiratory Burst Involved In Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Aggregation Cellular Oxidant Detoxification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of DNA-templated Transcription Proteolysis Autophagy Cell Population Proliferation Regulation Of Autophagy Protein Deubiquitination Melanocyte Differentiation Regulation Of Protein Stability Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein Protein K6-linked Deubiquitination Protein Stabilization Protein K63-linked Deubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs		Calcium Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 31619474) Basophil percentage of white cells ( 32888494) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		14 interacting genes: CDC42 EGFR MAGEA1 MAGEA3 MAGEA6 MAPK14 NCF2 PTEN S100A8 S100B SNCA TUBA1A TUBB USP13	30 interacting genes: AMFR ATG5 CCND1 CLK3 CSNK2A1 CTNNB1 DAZAP2 DVL1 DYRK1A FNBP1L FUNDC2 G3BP1 GPR160 HSP90AA1 LAPTM5 MDC1 MRPL20 MYO15A S100A9 SIAH2 SPRR2C SYCP2 TOPBP1 TRA2B TRIM55 TRIM63 TWIST1 UBC UBL4A UIMC1
Entrez ID		6280	8975
HPRD ID		00472	04666
Ensembl ID		ENSG00000163220	ENSG00000058056
Uniprot IDs		P06702	A0A0A6YZ17 Q92995
PDB IDs		1IRJ 1XK4 4GGF 4XJK 5I8N 5W1F 6DS2 7QUV 7UI5 8SJB 8SJC	2L80 2LBC
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Negative Regulation Of Catabolic Process Cell Projection Morphogenesis Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Growth Neuron Projection Morphogenesis Learning Or Memory Forebrain Morphogenesis RAGE Receptor Binding Regulation Of Growth Dendritic Spine Morphogenesis Cellular Developmental Process Cognition Negative Regulation Of Autophagy Regulation Of Signal Transduction Histone Deacetylase Binding Cell Differentiation Regulation Of Autophagy Dentate Gyrus Development Adult Behavior Regulation Of Cellular Component Organization Enzyme Binding Positive Regulation Of Cell Growth Nucleus Regulation Of Peptidyl-serine Phosphorylation Dendritic Spine Organization Response To Lipid Cytosol Regulation Of Cell Communication Regulation Of Signaling Cell Junction Organization Cell Migration Regulation Of Intracellular Signal Transduction Cytoskeleton-dependent Intracellular Transport Apoptotic Process Negative Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of Cell Population Proliferation Neuron Projection Organization Postsynapse Organization Tau Protein Binding Anatomical Structure Morphogenesis Programmed Cell Death Cell Death Extracellular Region Cytoplasm Response To Cytokine Negative Regulation Of Signaling Negative Regulation Of Cell Communication Multivesicular Body, Internal Vesicle Lumen	DNA Damage Checkpoint Signaling Protein Modification Process Wnt Signaling Pathway Protein Ubiquitination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Autophagic Cell Death Autophagy Protein Localization To Site Of Double-strand Break Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Intracellular Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Protein Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Negative Regulation Of Signal Transduction By P53 Class Mediator Post-translational Protein Modification Response To Stress Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Cycle Process Identical Protein Binding Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Stress Granule Assembly Ubiquitin Protein Ligase Binding Regulation Of DNA Metabolic Process Genitalia Morphogenesis Regulation Of Wnt Signaling Pathway Cellular Response To Stress Negative Regulation Of Wnt Signaling Pathway Wnt Signalosome Cardiac Muscle Cell Apoptotic Process Catabolic Process Protein Serine/threonine Kinase Activator Activity Nucleus Aggrephagy Striated Muscle Cell Apoptotic Process Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Protein-containing Complex Macromolecule Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Catabolic Process
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