RRAD and NME1

Number of citations of the paper that reports this interaction (PubMedID 10611312)
45

Data Source:
HPRD (in vivo, in vitro)

		RRAD	NME1
Description		RRAD, Ras related glycolysis inhibitor and calcium channel regulator	NME/NM23 nucleoside diphosphate kinase 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm Early Endosome Cytosol Membrane Ruffle Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding	Nucleotide Binding Magnesium Ion Binding DNA Binding RNA Binding DNA Endonuclease Activity DNA Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor GDP Binding Identical Protein Binding Ribosomal Small Subunit Binding ADP Binding Metal Ion Binding Farnesyl Diphosphate Kinase Activity Coenzyme A Binding Succinyl-CoA Binding Acetyl-CoA Binding
	Biological Process	Small GTPase-mediated Signal Transduction	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Apoptotic DNA Fragmentation Isoprenoid Metabolic Process Endocytosis Nervous System Development Lactation Negative Regulation Of Cell Population Proliferation Nucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process Cell Differentiation Mammary Gland Development Protein Hexamerization Regulation Of Fatty Acid Biosynthetic Process Regulation Of Apoptotic Process ITP Biosynthetic Process Acetyl-CoA Catabolic Process Positive Regulation Of Epithelial Cell Proliferation
Pathways		NGF-stimulated transcription	Interconversion of nucleotide di- and triphosphates Azathioprine ADME Ribavirin ADME
Drugs			Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Waist circumference adjusted for body mass index ( 34021172)	Bipolar disorder ( 31043756) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Metabolite levels ( 23823483)
Interacting Genes		15 interacting genes: CALM1 CAMK2G CCDC141 CSNK2A1 CSNK2B EEA1 EGFR MMP14 NME1 PRKACA PRKCA PRKCB STAT3 TPM2 YWHAZ	35 interacting genes: APEX1 AURKA CCND3 DDX19A FBXO24 FXR1 FXR2 GORASP2 ITGB1 KSR1 LNX1 MIF NIF3L1 NME3 NME4 NTAQ1 NUTF2 NXF1 PID1 POLR1C PRPF6 PRUNE1 RAC1 RORA RORB RRAD SET SMARCD1 SNCA SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 TNPO3
Entrez ID		6236	4830
HPRD ID		01536	01131
Ensembl ID		ENSG00000166592	ENSG00000239672
Uniprot IDs		P55042	A0A384MTW7 P15531
PDB IDs		2DPX 2GJS 3Q72 3Q7P 3Q7Q	1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4 8OOV
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylation Histone H3T6 Kinase Activity Cytosol Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase C Signaling Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Protein Phosphorylation Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Cytoplasm Regulation Of Signal Transduction Mitotic Nuclear Membrane Disassembly Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Establishment Of Protein Localization Identical Protein Binding Interleukin-2-mediated Signaling Pathway Intracellular Signaling Cassette Regulation Of Muscle System Process Positive Regulation Of Insulin Secretion Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphatase Binding Nuclear Membrane Disassembly ATP Binding Regulation Of Biological Quality Membrane Disassembly Negative Regulation Of Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Signal Transduction Calyx Of Held Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Estradiol Negative Regulation Of Glycolytic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion	Mitochondrion-mitochondrion Outer Membrane Tether Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission MRNA Transport RNA Transport Nuclear Import Signal Receptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Cytoplasm Nucleobase-containing Compound Transport Negative Regulation Of Biosynthetic Process Postsynapse Double-stranded Telomeric DNA Binding Cellular Component Assembly UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Transport Nucleocytoplasmic Transport Regulation Of Cell Differentiation Central Nervous System Neuron Differentiation Protein Hexamerization Protein Binding Regulation Of Cell Development Regulation Of Macrophage Activation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Development CTP Biosynthetic Process CTP Metabolic Process Regulation Of Microtubule Polymerization Protein-containing Complex Organization Nucleoside Diphosphate Kinase Activity Regulation Of Hydrogen Peroxide Metabolic Process Nucleus Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neurotransmitter Uptake Neuron Differentiation Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Nucleosome Disassembly Regulation Of Rho Protein Signal Transduction Regulation Of Neurogenesis GTP Metabolic Process Regulation Of Cell Maturation Protein-DNA Complex Disassembly
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