RPS6KA1 and CFL1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RPS6KA1	CFL1
Description		ribosomal protein S6 kinase A1	cofilin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Filopodium Axon Growth Cone Cortical Actin Cytoskeleton Cell Leading Edge Lamellipodium Membrane Mitochondrial Membrane Vesicle Ruffle Membrane Cell Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Cofilin-actin Rod Synaptic Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Actin Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Actin Filament Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Protein Phosphorylation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Cell Growth Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Import Into Nucleus Cytoskeleton Organization Actin Filament Organization Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Actin Polymerization Or Depolymerization Response To Virus Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Lamellipodium Assembly Response To Activity Hippocampus Development Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Cell Projection Organization Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Cell Growth Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Synaptic Plasticity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Response To Amino Acid Host-mediated Activation Of Viral Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Cell Motility Modulation Of Chemical Synaptic Transmission Actin Filament Severing Establishment Of Spindle Localization Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Ether Cellular Response To Epidermal Growth Factor Stimulus Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Cell Leading Edge Negative Regulation Of Postsynaptic Density Organization Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK Transcriptional and post-translational regulation of MITF-M expression and activity	Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Purvalanol A Fostamatinib	Dodecyldimethylamine N-oxide Copper Artenimol
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting plasma glucose ( 31932636) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155) White blood cell count ( 32888494)	Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		95 interacting genes: - ACSBG2 ARHGEF11 ARHGEF12 ASCC3 ATM ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP CXCL12 DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 IGFBP2 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NHERF2 NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RABGGTB RECK RPTOR SHANK3 SHROOM2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 STAT3 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB	47 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CD5 CLCN5 ERBB2 ERBB3 ERBB4 ESR1 FLNA FNDC3B HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP MYCBP2 NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SNRPA SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UBE2M UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		6195	1072
HPRD ID		03402	03261
Ensembl ID		ENSG00000117676	ENSG00000172757
Uniprot IDs		Q15418	P23528 V9HWI5
PDB IDs		2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62 6TWY 7P74 7PC8 7QQL 8WF4 8XOV	1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Cytoplasm Phosphatase Binding Regulation Of Cell Development Positive Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Cellular Component Organization Nuclear Glucocorticoid Receptor Binding Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Cellular Response To Heat Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of TOR Signaling Regulation Of Multicellular Organismal Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Protein Phosphorylation Cellular Response To Stress TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Developmental Process Negative Regulation Of Signal Transduction Regulation Of Osteoclast Differentiation Response To Peptide Hormone Regulation Of Multicellular Organismal Development Negative Regulation Of Autophagy Response To Decreased Oxygen Levels Regulation Of TOR Signaling Negative Regulation Of Catabolic Process Intracellular Protein Localization Negative Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Organelle Organization Response To Oxygen Levels Regulation Of Developmental Process PDZ Domain Binding Response To Nutrient Levels Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction	Actin Cytoskeleton Organization Actin Filament-based Process ATP Binding Regulation Of Organelle Organization Regulation Of Cellular Component Organization Nucleotide Binding Focal Adhesion Protein Modification Process Cytoplasm Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Protein Kinase Activity Regulation Of Multicellular Organismal Process Actin Filament Cytoskeleton Positive Regulation Of Multicellular Organismal Process Mesenchyme Migration Regulation Of Protein Localization To Nucleus Cytoskeleton Organization Regulation Of Membrane Potential Developmental Process Protein Phosphorylation Cell Junction Organization ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Actin Filament Organization Kinase Activity Protein-containing Complex Lamellipodium Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Phosphorylation Organelle Organization Positive Regulation Of Cell Activation Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Phosphatase Activity Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Protein Localization To Cell Junction Positive Regulation Of MAPK Cascade Negative Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Protein Serine/threonine Phosphatase Activity
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