RPS4Y1 and TMPRSS15

		RPS4Y1	TMPRSS15
Description		ribosomal protein S4 Y-linked 1	transmembrane serine protease 15
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Ribosome Membrane Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex	Brush Border Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome RRNA Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Translation	Proteolysis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases			Enterokinase deficiency
GWAS			Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)
Interacting Genes		4 interacting genes: CALM1 CLK1 MEOX2 TMPRSS15	7 interacting genes: GABPA GART HUNK M6PR RPL19 RPS4Y1 SPINK1
Entrez ID		6192	5651
HPRD ID		15963	05972
Ensembl ID		ENSG00000129824	ENSG00000154646
Uniprot IDs		P22090	P98073
PDB IDs		5AJ0 5FLX 6OLG 6OLZ	4DGJ 6ZOV 7WQX
Enriched GO Terms of Interacting Partners?		Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Somite Specification Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Segment Specification Somite Development Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of Transporter Activity Cellular Response To Interferon-beta Catalytic Complex Presynaptic Cytosol Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Cell Action Potential Calcineurin-mediated Signaling Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Myelin Sheath	Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity Ligase Activity, Forming Carbon-nitrogen Bonds Adenine Biosynthetic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Adenine Metabolic Process
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