RPN2 and FBN3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RPN2	FBN3
Description		ribophorin II	fibrillin 3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Nuclear Body Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Microfibril Extracellular Region Extracellular Matrix
	Molecular Function	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein Modification Process	Glucose Metabolic Process Signal Transduction Glucose Homeostasis Camera-type Eye Development Embryonic Eye Morphogenesis
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 31562340) Hippocampal atrophy ( 19668339) Initial pursuit acceleration in psychotic disorders ( 29064472) Kawasaki disease ( 33692975)	Attention deficit hyperactivity disorder ( 30563984) Macular telangiectasia type 2 ( 33654266) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Pre-treatment viral load in HIV-1 infection ( 31219150) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		17 interacting genes: ADRM1 BCL2L13 EZH2 FBN3 ISG15 LINC00632 LTB4R2 NDRG1 NGFR PDE4B PTEN RBBP4 RCHY1 RHOA SLC22A2 SMO WEE2-AS1	13 interacting genes: ANXA7 BID C11orf58 CDKN1A DAZAP2 GADD45A GSK3B NUDT21 PIK3R3 RPN2 RPS6KA6 TK1 TSC22D1
Entrez ID		6185	84467
HPRD ID		01609	10538
Ensembl ID		ENSG00000118705	ENSG00000142449
Uniprot IDs		P04844	A0A494C0D8 A8KAY2 Q75N90
PDB IDs		6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Dendritic Spine Negative Regulation Of Hair Follicle Development Regulation Of Protein Modification Process Negative Regulation Of Cell Size Forebrain Morphogenesis ESC/E(Z) Complex Myelin Maintenance Odontogenesis Negative Regulation Of Cell Migration Animal Organ Development Regulation Of Cell Migration Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Motility Regulation Of Cell Motility Negative Regulation Of Cell Communication Regulation Of Hair Cycle Regulation Of Hair Follicle Development Dentate Gyrus Development Negative Regulation Of Locomotion Regulation Of Locomotion Central Nervous System Development Hair Follicle Morphogenesis Molecular Function Inhibitor Activity Regulation Of Protein Phosphorylation Gamma-tubulin Binding Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Kidney Development Negative Regulation Of Multicellular Organismal Process Regulation Of Phosphorylation Regulation Of Cell Development Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Hepatocyte Homeostasis Homeostasis Of Number Of Cells Hair Follicle Development Negative Regulation Of Synaptic Vesicle Clustering Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorus Metabolic Process Rho Protein Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell-substrate Adhesion Aortic Valve Formation Regulation Of Focal Adhesion Assembly	Signal Transduction In Response To DNA Damage Positive Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Nuclear Body Protein Serine/threonine Kinase Binding Positive Regulation Of Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Catalytic Activity Regulation Of Programmed Cell Death Negative Regulation Of Developmental Process Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Apoptotic Signaling Pathway Regulation Of Membrane Permeability Negative Regulation Of Kinase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Reactive Oxygen Species Metabolic Process PCNA-p21 Complex Cell Cycle G1/S Phase Transition Negative Regulation Of Cardiac Muscle Tissue Regeneration G1/S Transition Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein P53 Binding Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Stem Cell Differentiation Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Insulin Receptor Signaling Pathway Thymidine Kinase Activity Positive Regulation Of Pro-B Cell Differentiation Negative Regulation Of Embryonic Development DNA Damage Response Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction DNA Synthesis Involved In Mitotic DNA Replication Protein Tetramerization Positive Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Mesoderm Development Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Protein Phosphorylation Cellular Response To Cell-matrix Adhesion Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation
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