RPL28 and STAU1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RPL28	STAU1
Description		ribosomal protein L28	staufen double-stranded RNA binding protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Dendrite Cytoplasmic Ribonucleoprotein Granule Cell Body Synapse Extracellular Exosome Ribonucleoprotein Complex	Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Microtubule Associated Complex Plasma Membrane Cytoplasmic Stress Granule Membrane Dendrite Dendrite Cytoplasm Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Neuronal Cell Body Cell Body Extracellular Exosome Glutamatergic Synapse
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	RNA Binding Double-stranded RNA Binding MRNA Binding Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Cytoplasmic Translation Translation	LncRNA-mediated Post-transcriptional Gene Silencing Germ Cell Development Intracellular MRNA Localization Cellular Response To Oxidative Stress Protein Localization To Synapse Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Modulation Of Chemical Synaptic Transmission Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Modification Of Postsynaptic Structure Positive Regulation Of Long-term Synaptic Potentiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Retinitis pigmentosa ( 33514863)	Anger ( 24489884) Appendicular lean mass ( 33097823) Change in quality of life in response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease ( 31299468) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 32581322) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196 25282103) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889 31518406) Loneliness (MTAG) ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		9 interacting genes: CCNDBP1 FNDC3B FOXP1 MAP2K5 PTEN SGO1 SMAD4 STAU1 TMEM230	49 interacting genes: ADARB1 APP CASC3 CDC42 CEBPA CFTR CSNK2B DHX9 DYNC1I1 FMR1 FOXP1 GLRX3 HNRNPU INA IQGAP1 KIF2B LINC00624 LONRF1 MAP1B MAPT MYH1 NCBP1 NCL NEIL3 NKRF NXT1 OGT PABPC1 PABPN1 PPP1CA RAC1 RASA1 ROCK2 RPL28 RPL6 RPL7A RPLP0 RPS6 SPP1 SRPK1 STRBP TAX1BP3 TINCR TUBB TUBB4A UBE2D3 UPF1 USP7 ZMAT3
Entrez ID		6158	6780
HPRD ID		04702	03422
Ensembl ID		ENSG00000108107	ENSG00000124214
Uniprot IDs		H0YKD8 P46779	B3KRE0 O95793 Q59F99 Q6PJX3
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKQ 8FKS 8FKU 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO	4DKK 6HTU 6SDW 6SDY
Enriched GO Terms of Interacting Partners?		Endothelial Cell Activation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Growth Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Growth Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Organ Growth Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Intracellular Signal Transduction Gonad Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Nephrogenic Mesenchyme Morphogenesis Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Growth Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis ERK5 Cascade Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Organ Growth Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Axo-dendritic Transport Positive Regulation Of Interleukin-21 Production Negative Regulation Of Developmental Growth Regulation Of Chemokine Production Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Metanephric Mesenchyme Morphogenesis Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Mitotic Sister Chromatid Cohesion, Centromeric Osteoblast Differentiation Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of System Process Sulfate Binding Endocardial Cell Differentiation Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Smooth Muscle Cell Proliferation	Cytoplasmic Ribonucleoprotein Granule Ribonucleoprotein Complex RNA Binding Cytosol Cytoplasm Nucleus Regulation Of Translation Regulation Of MRNA Metabolic Process MRNA Export From Nucleus Dendrite MRNA Transport Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing RNA Export From Nucleus RNA Transport Postsynapse Negative Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Viral Process Cytoskeleton-dependent Intracellular Transport Cytoplasmic Translation Nuclear Export Negative Regulation Of Metabolic Process Nucleobase-containing Compound Transport Negative Regulation Of Macromolecule Metabolic Process Regulation Of Viral Process MRNA Processing Cell Body Regulation Of Cytoplasmic Translation CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleic Acid Metabolic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Protein-containing Complex Binding MRNA Binding Cytosolic Ribosome Positive Regulation Of Supramolecular Fiber Organization Transport Along Microtubule Regulation Of Supramolecular Fiber Organization Nuclear-transcribed MRNA Catabolic Process Cellular Localization Regulation Of RNA Splicing Regulation Of Viral Life Cycle Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation
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