SCOC and DOK5

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		SCOC	DOK5
Description		short coiled-coil protein	docking protein 5
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Positive Regulation Of Macroautophagy Regulation Of Protein Complex Stability	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Differentiation Positive Regulation Of MAPK Cascade Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Pathways		Retrograde transport at the Trans-Golgi-Network	RET signaling
Drugs
Diseases
GWAS		Malaria ( 31844061) Smoking status (ever vs never smokers) ( 30643258)	Celiac disease ( 23936387) Erectile dysfunction ( 30583798) Functional MRI ( 20215924) HDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		14 interacting genes: ARL1 BFSP2 DDIT4L DOK5 FEZ1 ITSN1 KIFC3 KRT40 MAPK8 PSMC5 SCHIP1 SIKE1 TCF4 TRAPPC6A	20 interacting genes: AHDC1 ATF3 BNIP3L CCDC85B CDCA4 DOK3 EGFR FANCG IGF1R INSR NTRK2 NTRK3 OLIG1 OPRM1 PFDN5 RAI2 RET SCOC TSC1 WIZ
Entrez ID		60592	55816
HPRD ID		18027	16317
Ensembl ID		ENSG00000153130	ENSG00000101134
Uniprot IDs		A0A0C4DGB0 A0A804E055 Q9UIL1	Q9P104
PDB IDs		4BWD 7AA7	1J0W
Enriched GO Terms of Interacting Partners?			Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Insulin Receptor Activity Axon Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Complex Neurotrophin Receptor Activity Neurotrophin Binding Insulin Binding Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Kinase Activity Dendritic Spine Maintenance Action Potential Propagation Neuronal Action Potential Propagation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Insulin-like Growth Factor I Binding Insulin Receptor Substrate Binding Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Endosome Phosphatidylinositol 3-kinase Binding Myelination Axon Ensheathment Myelination In Peripheral Nervous System Learning Or Memory Positive Regulation Of Cell Junction Assembly Cellular Response To Growth Factor Stimulus Endosome Membrane Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Nervous System Process Protein Autophosphorylation Amyloid-beta Clearance Mechanoreceptor Differentiation Cognition Positive Regulation Of Cell Motility Response To Growth Factor Positive Regulation Of Cell Population Proliferation Neurotrophin Signaling Pathway Positive Regulation Of Locomotion
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