RNF4 and TRIM38

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF4	TRIM38
Description		ring finger protein 4	tripartite motif containing 38
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End	Cytoplasm Cytosol
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Damage Response Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly Negative Regulation Of Protein Localization To Chromatin	Immune System Process Regulation Of Gene Expression Protein Ubiquitination Protein Sumoylation Regulation Of Interferon-beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Process Negative Regulation Of Defense Response To Virus Protein K48-linked Ubiquitination Regulation Of Viral Life Cycle
Pathways		Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)	A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Fish- and plant-related diet ( 32066663) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		141 interacting genes: AIM2 AKAP17A AR ARID3C ARK2N ATF2 ATXN1 BCL2L1 BIRC6 BLM BTBD1 BTBD3 C14orf119 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH EIF2A ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK ID1 IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PARP1 PATZ1 PCBP3 PGR PHC1 PRMT5 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8 RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TOP2B TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UCHL1 UCHL5 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2	34 interacting genes: ATXN1 BYSL EIF1B GMCL1 GORASP2 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 MTMR6 MTURN PIAS4 PSMA4 RFC5 RIPK1 RNF4 SDCBP SOX2 SPTLC1 STXBP1 TCEA2 TSBP1 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U ZNF764
Entrez ID		6047	10475
HPRD ID		04167	15555
Ensembl ID		ENSG00000063978	ENSG00000112343
Uniprot IDs		P78317	O00635
PDB IDs		2EA6 2XEU 4PPE
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Ubiquitin Conjugating Enzyme Activity Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Ubiquitin-protein Transferase Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II Keratinization Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Monoubiquitination Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein-containing Complex DNA Damage Response Positive Regulation Of Metabolic Process Signaling Adaptor Activity Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Nucleic Acid Metabolic Process Thioesterase Binding	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination ATP Binding Protein Refolding Protein Polyubiquitination ATP-dependent Protein Folding Chaperone Protein K11-linked Ubiquitination Ubiquitin-protein Transferase Activity Nucleotide Binding Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation C3HC4-type RING Finger Domain Binding Protein Folding Chaperone Blood Microparticle ATP-dependent Protein Disaggregase Activity Heat Shock Protein Binding Post-translational Protein Modification Response To Unfolded Protein Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Protein Ubiquitination Unfolded Protein Binding Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification Process Nucleoplasm Regulation Of Inclusion Body Assembly Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Transferase Activity Protein K63-linked Ubiquitination Protein K6-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus ISG15 Transferase Activity Ubiquitin Protein Ligase Binding Cellular Response To Stress Regulation Of Spindle Assembly Catabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Metabolic Process Protein Folding Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Protein Localization To Chromatin ISG15-protein Conjugation Positive Regulation Of Myeloid Cell Differentiation ATP Hydrolysis Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?