RNF2 and KAT8

Number of citations of the paper that reports this interaction (PubMedID 15960975)
0

Data Source:
HPRD (in vivo)

		RNF2	KAT8
Description		ring finger protein 2	lysine acetyltransferase 8
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Heterochromatin Sex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Chromosome Mitochondrion Nuclear Matrix Nuclear Lumen NuA4 Histone Acetyltransferase Complex NSL Complex MLL1 Complex MSL Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding Histone H2AK119 Ubiquitin Ligase Activity	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Enzyme Binding Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-lysine-acetyltransferase Activity Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Chromatin Organization Chromatin Remodeling Germ Cell Development Anterior/posterior Axis Specification Gene Expression Protein Ubiquitination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity	Epithelial To Mesenchymal Transition Chromatin Organization Regulation Of DNA-templated Transcription Dosage Compensation By Inactivation Of X Chromosome Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Skeletal Muscle Satellite Cell Differentiation Neurogenesis Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Post-embryonic Hemopoiesis Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oogenesis Regulation Of MRNA Processing Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Membraneless Organelle Assembly Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Regulation Of Mitochondrial Transcription
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes		65 interacting genes: ABCB1 AMBRA1 BAALC BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 CIP2A DYSF ERG GMNN H2AC18 H2AC20 H2AC4 H2BC3 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF1 PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SBDS SCMH1 SIK1 SMURF2 SSX2 TARDBP TFCP2 TMEM132D TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 WASHC1	26 interacting genes: ATM BAZ1B BAZ2A CEBPA CFAP119 CLEC4A FOXP3 H2AC8 H3C1 H4C1 H4C7 KMT2A LIMS1 NFATC2IP ORAI3 PAF1 PLAU PRRT2 RABEP2 RNF2 SLC7A5P1 SRY SSTR5 TP53 TP53BP1 ZNF764
Entrez ID		6045	84148
HPRD ID		07028	11381
Ensembl ID		ENSG00000121481	ENSG00000103510
Uniprot IDs		Q99496	Q9H7Z6
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG	2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR 8W13
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity PRC1 Complex PcG Protein Complex Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Nucleus Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Nucleoplasm Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Proteolysis Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Chromatin Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Transferase Activity Heterochromatin Formation Heterochromatin Proteasomal Protein Catabolic Process Sex Chromatin Protein Monoubiquitination Negative Regulation Of Transcription By RNA Polymerase II	Chromatin Remodeling Chromatin Organization DNA Binding Epigenetic Regulation Of Gene Expression Response To X-ray Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein Heterodimerization Activity Structural Constituent Of Chromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Chromosome Nucleosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Chromosome Negative Regulation Of DNA Recombination Negative Regulation Of Cell Population Proliferation Cellular Response To X-ray Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-DNA Complex Assembly DNA Repair Complex DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Chromosome Organization Replicative Senescence Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Organelle Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Or Lymphoid Organ Development Site Of Double-strand Break DNA Damage Checkpoint Signaling Alpha-beta T Cell Activation Regulation Of Cell Population Proliferation Regulation Of Integrin-mediated Signaling Pathway
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