TGIF2 and RBBP8

Number of citations of the paper that reports this interaction (PubMedID 11427533)
0

Data Source:
HPRD (in vivo)

		TGIF2	RBBP8
Description		TGFB induced factor homeobox 2	RB binding protein 8, endonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Centrosome	Nucleus Nucleoplasm Chromosome Transcription Repressor Complex Site Of Double-strand Break BRCA1-C Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Damaged DNA Binding Transcription Corepressor Activity Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Gastrulation Neuron Differentiation Amacrine Cell Differentiation Nodal Signaling Pathway Retina Development In Camera-type Eye Positive Regulation Of Amacrine Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Blastocyst Hatching DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Homologous Recombination Mitotic G2/M Transition Checkpoint Negative Regulation Of DNA-templated Transcription Cell Division Meiotic Cell Cycle DNA Strand Resection Involved In Replication Fork Processing
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Negative Regulation of CDH1 Gene Transcription	HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Seckel syndrome
GWAS			Eosinophil percentage of white cells ( 27863252) Estradiol levels ( 34255042) Height ( 18391951 25429064) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte count ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		6 interacting genes: FBXO7 HDAC1 PLS3 RBBP8 SMAD3 TARBP2	40 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PAN2 PCNA PELI2 PIAS4 PIN1 PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 RNF4 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 UBE2I USP4
Entrez ID		60436	5932
HPRD ID		06293	04990
Ensembl ID		ENSG00000118707	ENSG00000101773
Uniprot IDs		Q9GZN2	Q99708
PDB IDs			1Y98 2L4Z 4D2H 7BGF
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Endoderm Development MiRNA Processing Enzyme Binding Transcription Repressor Complex Promoter-specific Chromatin Binding Transcription Corepressor Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Structural Constituent Of Presynaptic Actin Cytoskeleton Regulation Of SiRNA Processing Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Ubiquitin Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Krueppel-associated Box Domain Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Muscle Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Decrotonylase Activity Negative Regulation Of Cell Differentiation Histone Decrotonylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Regulation Of Cell Differentiation Sterol Response Element Binding Regulation Of Lung Blood Pressure Paraxial Mesoderm Morphogenesis Negative Regulation Of Mitotic Cell Cycle Phase Transition Global Gene Silencing By MRNA Cleavage Negative Regulation Of Defense Response To Virus By Host Lewy Body Core Negative Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Binding Hair Follicle Placode Formation Regulation Of Intrinsic Apoptotic Signaling Pathway Mesoderm Morphogenesis Immune System Development Transcription Corepressor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Transdifferentiation SMAD Protein Complex Pericardium Development Trophoblast Cell Migration Presynaptic Cytoskeleton Organization Presynaptic Actin Cytoskeleton Organization	Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Post-translational Protein Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Protein Modification Process BRCA1-B Complex Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mitotic G2/M Transition Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Ubiquitination Mitotic G2 DNA Damage Checkpoint Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Homologous Recombination Nucleoplasm Regulation Of Apoptotic Signaling Pathway Protein Polyubiquitination DNA Strand Resection Involved In Replication Fork Processing
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