BCL3 and N4BP2

Number of citations of the paper that reports this interaction (PubMedID 12730195)
0

Data Source:
HPRD (in vitro, in vivo)

		BCL3	N4BP2
Description		BCL3 transcription coactivator	NEDD4 binding protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Midbody Protein-containing Complex Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein-macromolecule Adaptor Activity Histone Deacetylase Binding DNA-binding Transcription Factor Binding	Nucleotide Binding Endonuclease Activity DNA Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity Ubiquitin Binding ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Negative Regulation Of Cytokine Production Follicular Dendritic Cell Differentiation Marginal Zone B Cell Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Germinal Center Formation Protein Import Into Nucleus Apoptotic Process Response To Stress DNA Damage Response Canonical NF-kappaB Signal Transduction Response To Virus Response To UV-C Positive Regulation Of Gene Expression Antimicrobial Humoral Response Extracellular Matrix Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production T-helper 1 Type Immune Response Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Defense Response To Protozoan Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process T-helper 2 Cell Differentiation Positive Regulation Of Translation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Spleen Development Regulation Of DNA Binding Response To Other Organism T Cell Apoptotic Process Negative Regulation Of T Cell Apoptotic Process Regulation Of Non-canonical NF-kappaB Signal Transduction	DNA Metabolic Process
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 24755620 30636644) Alzheimer's disease (late onset) ( 23565137) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Asthma ( 32296059) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Platelet thrombus formation ( 22550155)
Interacting Genes		36 interacting genes: AKT1 ANKRD28 BARD1 CHUK COPS5 CREBBP CTBP1 CTBP2 CTNNB1 EP300 FOS FYN GSK3A GSK3B GTF2A1 GTF2B HDAC1 HDAC3 HDAC6 JUN KAT5 MAPK1 MAPK3 MAPRE1 N4BP2 NCOA1 NFKB1 NFKB2 PIR RAB9A RELA RUVBL2 RXRA SHC1 TBP TRAF6	5 interacting genes: BCL3 CREBBP EP300 NEDD4 TOLLIP
Entrez ID		602	55728
HPRD ID		00179	11382
Ensembl ID		ENSG00000069399	ENSG00000078177
Uniprot IDs		B7Z3N9 P20749	B2ZZ87 Q86UW6
PDB IDs		1K1A 1K1B	2D9I 2VKC 3BHB 3FAU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Response To Lipid Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Intracellular Signal Transduction Regulation Of Gene Expression Nucleoplasm RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Transcription By RNA Polymerase II Cytosol Enzyme Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Chromatin Binding Nucleus Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Tau Protein Binding Regulation Of Apoptotic Process Transcription Corepressor Binding Macromolecule Biosynthetic Process Macromolecule Metabolic Process	Response To UV Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Canonical NF-kappaB Signal Transduction Response To Light Stimulus Cellular Response To UV Response To Radiation Cellular Response To Light Stimulus Transcription Coregulator Activity N-terminal Protein Amino Acid Acetylation Leukocyte Activation Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Protein Localization To Organelle Cell Activation Cellular Response To Radiation DNA-binding Transcription Factor Binding Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Protein-containing Complex Histone Acetyltransferase Complex DNA Damage Response Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Acetylation Transcription Coactivator Activity Tau Protein Binding Regulation Of Cellular Response To Growth Factor Stimulus Transcription Coactivator Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein Destabilization Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Damaged DNA Binding P53 Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response Lymphocyte Activation Positive Regulation Of Macromolecule Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Stress Negative Regulation Of RNA Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?