RLF and PPT1

		RLF	PPT1
Description		RLF zinc finger	palmitoyl-protein thioesterase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Nucleus Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Synaptic Vesicle Membrane Axon Dendrite Synaptic Vesicle Membrane Neuronal Cell Body Lysosomal Lumen Membrane Raft Extracellular Exosome Presynaptic Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity Phospholipase A2 Inhibitor Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Hydrolase Activity Palmitoyl Hydrolase Activity Sulfatide Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Heterochromatin Formation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Protein Depalmitoylation Endocytosis Receptor-mediated Endocytosis Pinocytosis Lysosome Organization Lysosomal Lumen Acidification Neurotransmitter Secretion Nervous System Development Brain Development Visual Perception Grooming Behavior Associative Learning Adult Locomotory Behavior Macromolecule Catabolic Process Protein Transport Lipid Catabolic Process Sphingolipid Catabolic Process Protein Catabolic Process Negative Regulation Of Cell Growth Membrane Raft Organization Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Pinocytosis Neuron Development Regulation Of Synapse Structure Or Activity
Pathways			Fatty acyl-CoA biosynthesis
Drugs			Hexadecanesulfonyl fluoride Palmitic Acid
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		High density lipoprotein cholesterol levels ( 30498476) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Blood protein levels ( 30072576) Platelet count ( 32888494)
Interacting Genes		8 interacting genes: CLK1 FBXL17 GCH1 PPT1 PRPF40A RIT1 RIT2 TRIM14	5 interacting genes: COL6A3 EPS15 GNAQ LCOR RLF
Entrez ID		6018	5538
HPRD ID		01614	07203
Ensembl ID		ENSG00000117000	ENSG00000131238
Uniprot IDs		Q13129	P50897 Q5T0S4
PDB IDs			3GRO
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Cyclohydrolase I Activity GTP Binding GDP Binding G Protein Activity Ras Protein Signal Transduction
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