RHO and SAG

Number of citations of the paper that reports this interaction (PubMedID 1917988)
0

Data Source:
HPRD (in vivo, in vitro)

		RHO	SAG
Description		rhodopsin	S-antigen visual arrestin
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Golgi-associated Vesicle Membrane Photoreceptor Outer Segment Membrane Cell Projection Ciliary Membrane Photoreceptor Inner Segment Membrane Sperm Midpiece Photoreceptor Disc Membrane Rod Photoreceptor Outer Segment Sperm Head Plasma Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytosol Membrane Cell Projection
	Molecular Function	G Protein-coupled Receptor Activity 11-cis Retinal Binding Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity Metal Ion Binding	G Protein-coupled Receptor Binding Opsin Binding Protein Phosphatase Inhibitor Activity Protein Binding Spectrin Binding Phosphoprotein Binding
	Biological Process	Microtubule Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Response To Light Stimulus Detection Of Light Stimulus Response To Light Intensity Gene Expression Absorption Of Visible Light G Protein-coupled Opsin Signaling Pathway Thermotaxis Photoreceptor Cell Maintenance Sensory Perception Of Light Stimulus Detection Of Temperature Stimulus Involved In Thermoception Retina Development In Camera-type Eye Cellular Response To Light Stimulus Podosome Assembly Rod Bipolar Cell Differentiation	G Protein-coupled Receptor Internalization Signal Transduction Cell Surface Receptor Signaling Pathway Sensory Perception G Protein-coupled Opsin Signaling Pathway
Pathways		The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Halothane N-Acetylmethionine 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine B-nonylglucoside Phosphonothreonine B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Dodecyldimethylamine N-oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane e Dexfosfoserine
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)
GWAS		Diisocyanate-induced asthma ( 25918132) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Calcium levels ( 20705733) Crohn's disease ( 22412388) Estimated glomerular filtration rate ( 31152163) Mild obesity-related type 2 diabetes ( 34737425)
Interacting Genes		12 interacting genes: ARR3 ARRB2 CD79A DERL1 GNGT1 GRK1 GRK2 GRK5 GRK6 PPP2CA PRKCA SAG	5 interacting genes: ADRA1B CHRM2 CLK3 EIF4E2 RHO
Entrez ID		6010	6295
HPRD ID		01584	01625
Ensembl ID		ENSG00000163914	ENSG00000130561
Uniprot IDs		P08100	P10523
PDB IDs		4ZWJ 5DGY 5W0P 6CMO
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Signal Transduction G Protein-coupled Receptor Internalization Photoreceptor Outer Segment Receptor Internalization G Protein-coupled Receptor Binding Opsin Binding Phototransduction Protein Serine/threonine Kinase Activity Receptor-mediated Endocytosis G Protein-coupled Opsin Signaling Pathway G Protein-coupled Receptor Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Photoreceptor Inner Segment Detection Of Light Stimulus Negative Adaptation Of Signaling Pathway Tachykinin Receptor Signaling Pathway Protein Kinase Activity Kinase Activity Detection Of Abiotic Stimulus Photoreceptor Disc Membrane Endocytosis Nervous System Process System Process Sensory Perception Membrane Phosphoprotein Binding Positive Regulation Of Cardiac Muscle Hypertrophy Postsynaptic Signal Transduction Negative Regulation Of Relaxation Of Smooth Muscle Import Into Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Detection Of Stimulus RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Edg-2 Lysophosphatidic Acid Receptor Binding Angiotensin Receptor Binding Response To Light Stimulus RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Derlin-1-VIMP Complex Protein Phosphorylation	Alpha1-adrenergic Receptor Activity Regulation Of Heart Contraction Regulation Of Muscle Contraction G Protein-coupled Receptor Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuron-glial Cell Signaling G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity Detection Of Temperature Stimulus Involved In Thermoception G Protein-coupled Opsin Signaling Pathway Rod Bipolar Cell Differentiation Photoreceptor Inner Segment Membrane 11-cis Retinal Binding Sperm Head Plasma Membrane Thermotaxis Absorption Of Visible Light MRNA Cap Binding Adrenergic Receptor Activity Regulation Of Blood Circulation Regulation Of Muscle System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Arrestin Family Protein Binding Retinal Bipolar Neuron Differentiation Photoreceptor Activity Podosome Assembly Rod Photoreceptor Outer Segment Cholinergic Synapse Photoreceptor Outer Segment Membrane G Protein-coupled Photoreceptor Activity Phototransduction, Visible Light RNA Cap Binding RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Golgi-associated Vesicle Membrane Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Light Intensity Glutamatergic Neuron Differentiation G Protein-coupled Acetylcholine Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Photoreceptor Disc Membrane Translation Factor Activity, RNA Binding Adrenergic Receptor Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Detection Of Temperature Stimulus Detection Of Visible Light Protein Serine/threonine/tyrosine Kinase Activity
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